Repository describing an aging population to inform physiologically based pharmacokinetic models considering anatomical, physiological, and biological... (Publications)
BACKGROUND: Aging is characterized by anatomical, physiological, and biological changes that can impact drug kinetics. The elderly are often excluded from clinical trials and knowledge about drug kine
Investigation of the plasma virome from cases of unexplained febrile illness in Tanzania from 2013 to 2014: a comparative analysis between unbiased... (Publications)
High-throughput sequencing can provide insights into epidemiology and medicine through comprehensive surveys of viral genetic sequences in environmental and clinical samples. Here, we characterize the
Performance of the point-of-care circulating cathodic antigen (POC-CCA) urine cassette test for follow-up after treatment of<em> S. mansoni... (Publications)
BACKGROUND: Point-of-care circulating cathodic antigen (POC-CCA) urine cassette testing has become a popular approach to screen for Schistosoma infection. Since the test is also increasingly used for
3D-QSAR modeling and synthesis of new fusidic acid derivatives as antiplasmodial agents (Publications)
Wide spread Plasmodium falciparum ( P. falciparum) resistance has compromised existing antimalarial therapies to varying degrees. Novel agents, able to circumvent antimalarial drug resistance, are the
Effects of vancomycin and ciprofloxacin on the NMRI mouse metabolism (Publications)
The reduction in gut microbiota diversity is associated with a range of human diseases. Overuse of antibiotics has been associated with a diminished gut-microbial diversity in humans, and may promote
Molecular assays for antimalarial drug resistance surveillance: a target product profile (Publications)
Antimalarial drug resistance is a major constraint for malaria control and elimination efforts. Artemisinin-based combination therapy is now the mainstay for malaria treatment. However, delayed parasi
The prevalence of brucellosis and bovine tuberculosis in ruminants in Sidi Kacem Province, Morocco (Publications)
Bovine tuberculosis (BTB) and brucellosis are major endemic zoonoses in ruminants in Morocco that impact on both animal and human health. This study presents an assessment of the epidemiological and s
The Comparative Effectiveness of Innovative Treatments for Cancer (CEIT-Cancer) project: rationale and design of the database and the collection of... (Publications)
BACKGROUND: The available evidence on the benefits and harms of novel drugs and therapeutic biologics at the time of approval is reported in publicly available documents provided by the US Food and Dr
