Comparing systemic metabolic responses in mice to single or dual infection with <em>Plasmodium berghei</em> and <em>Heligmosomoides bakeri</em> (Publications)
Concomitant infections with Plasmodium and gastrointestinal nematodes are frequently observed in humans. At the metabolic level, the cross-talk between the host and multiple coexisting pathogens is po
Helminth products bypass the need for TSLP in Th2 immune responses by directly modulating dendritic cell function (Publications)
Thymic stromal lymphopoietin (TSLP) is an interleukin (IL)-7-like cytokine, mainly expressed by epithelial cells, and key to the development of allergic responses. The well-documented involvement of T
Lipidomics identifies a requirement for peroxisomal function during influenza virus replication (Publications)
Influenza virus acquires a host-derived lipid envelope during budding, yet a convergent view on the role of host lipid metabolism during infection is lacking. Using a mass spectrometry-based lipidomic
<em>In vitro</em> and<em> In vivo</em> evaluation of 28DAP010, a novel diamidine for treatment of second-stage African sleeping sickness (Publications)
African sleeping sickness is a neglected tropical disease transmitted by tsetse flies. New and better drugs are still needed especially for its second stage, which is fatal if untreated. 28DAP010, a d
Delayed anemia after treatment with injectable artesunate in the democratic republic of the Congo: a manageable issue (Publications)
Cases of delayed hemolytic anemia have been described after treatment with injectable artesunate, the current World Health Organization-recommended first-line drug for the treatment of severe malaria.
HPLC-based activity profiling for antiplasmodial compounds in the traditional Indonesian medicinal plant <em>Carica papaya</em> L (Publications)
ETHNOPHARMACOLOGICAL RELEVANCE: Leaf decoctions of Carica papaya have been traditionally used in some parts of Indonesia to treat and prevent malaria. Leaf extracts and fraction have been previously s
