Loss of genomic diversity in a <em>Neisseria meningitidis</em> clone through a colonization bottleneck (Publications)
Neisseria meningitidis is the leading cause of epidemic meningitis in the 'meningitis belt' of Africa, where clonal waves of colonization and disease are observed. Point mutations and horizontal gene
Expanding the rubterolone family: intrinsic reactivity and directed diversification of PKS-derived pyrans (Publications)
We characterized two key biosynthetic intermediates of the intriguing rubterolone family (tropolone alkaloids) that contain a highly reactive pyran moiety (in equilibrium with the hydrolyzed 1,5-dione
Fostering population-based cohort data discovery: the Maelstrom Research cataloguing toolkit (Publications)
BACKGROUND: The lack of accessible and structured documentation creates major barriers for investigators interested in understanding, properly interpreting and analyzing cohort data and biological sam
Virus detection by high-throughput sequencing of small RNAs: large scale performance testing of sequence analysis strategies (Publications)
Recent developments in high-throughput sequencing (HTS), also called next-generation sequencing (NGS), technologies and bioinformatics have drastically changed research on viral pathogens and spurred
Adverse impact of nocturnal transportation noise on glucose regulation in healthy young adults: effect of different noise scenarios (Publications)
BACKGROUND: Epidemiological evidence indicates an association between transportation noise exposure and a higher risk of developing type 2 diabetes. Sleep disturbances are thought to be one of the mec
The contribution of livestock to urban resilience: the case of Bamako, Mali (Publications)
Urban livestock keeping is increasing in many sub-Saharan African cities, but detailed contextual information on its extent, challenges, and potential is limited. A cross-sectional household study was
Analysis of interventions against the liver fluke, opisthorchis viverrini (Publications)
We adapt a population-based model of Opisthorchis viverrini transmission dynamics to determine the effectiveness of three different interventions. The model includes the definitive hosts, humans; the
Strategies to improve the medical device life cycle in Mexico (Publications)
OBJECTIVE: To analyze the role of stakeholders to three alternative strategies to improve processes and practices regarding the regulation, assessment, and management of orthopaedic medical devices in
Development and validation of a LC-MS/MS method for ivermectin quantification in dried blood spots: application to a pharmacokinetic study in... (Publications)
Ivermectin serves as a good addition to the small group of medications for soil-transmitted helminths, particularly against Trichuris trichiura infections. So far, ivermectin has been poorly character
