Expression of a specific variant surface glycoprotein has a major impact on suramin sensitivity and endocytosis in <em>Trypanosoma brucei</em> (Publications)
Suramin was introduced into the clinic a century ago and is still used to treat the first stage of acute human sleeping sickness. Due to its size and sixfold negative charge, uptake is mediated throug
Applied mathematical modelling to inform national malaria policies, strategies and operations in Tanzania (Publications)
BACKGROUND: More than ever, it is crucial to make the best use of existing country data, and analytical tools for developing malaria control strategies as the heterogeneity in malaria risk within coun
Effects of transportation noise and particulate matter on the cardiovascular system: what is the new evidence? (Publications)
SUMMARY: Several decades of research provides compelling evidence that exposure to air pollution causes various diseases. Time series studies in Europe and the USA examined the short term effects on m
Discovery and optimization of a compound series active against <em>Trypanosoma cruzi</em>, the causative agent of chagas disease (Publications)
Chagas disease is caused by the protozoan parasite Trypanosoma cruzi. It is endemic in South and Central America and recently has been found in other parts of the world, due to migration of chronicall
Better data for better outcomes: the importance of process mapping and management in CRVS systems (Publications)
BACKGROUND: Despite attempts to apply standard methods proven to work in high-income nations, nearly all civil registration and vital statistics (CRVS) systems in low- and middle-income countries are
Prospective assessment of loss to follow-up: incidence and associated factors in a cohort of HIV-positive adults in rural Tanzania (Publications)
INTRODUCTION: Lifelong antiretroviral therapy (ART) improves health outcomes for HIV-positive individuals, but is jeopardized by irregular clinic attendance and hence poor adherence. Loss to follow-up
Where there is no hospital: improving the notification of community deaths (Publications)
BACKGROUND: Globally, an estimated two-thirds of all deaths occur in the community, the majority of which are not attended by a physician and remain unregistered. Identifying and registering these dea
Comparing the lung cancer burden of ambient particulate matter using scenarios of air quality standards versus acceptable risk levels (Publications)
OBJECTIVES: Ambient particulate matter (PM) is regulated with science-based air quality standards, whereas carcinogens are regulated with a number of "acceptable" cases. Given that PM is also carcinog
Patterns of benzodiazepine prescription among older adults in Switzerland: a cross-sectional analysis of claims data (Publications)
OBJECTIVE: This study aimed to examine the prevalence and determinants of benzodiazepine prescription among older adults in Switzerland, and analyse association with hospitalisation and costs. DESIGN:
Long-term immunogenicity after yellow fever vaccination in immunosuppressed and healthy individuals (Publications)
BACKGROUND: The live-attenuated yellow fever vaccine (YFV) is generally contraindicated in immunosuppressed patients. Our aim was to investigate if immunosuppressive therapy impairs the long-term prot
