1,2-substituted 4-(1H)-quinolones: synthesis, antimalarial and antitrypanosomal activities in vitro (Publications)
A diverse array of 4-(1H)-quinolone derivatives bearing substituents at positions 1 and 2 were synthesized and evaluated for antiprotozoal activities against Plasmodium falciparum and Trypanosoma bruc
Multilevel analysis of childbearing in childhood in Tanzania's Rufiji district (Publications)
Objectives To examine levels, trends and correlates of childbearing in childhood (CiC) in the Rufiji district of Tanzania from 2002 to 2010. Methods Using longitudinal data collected in, and by, the R
Assessment of global guidelines for preventive chemotherapy against schistosomiasis and soil-transmitted helminthiasis: a cost-effectiveness modelling... (Publications)
BACKGROUND: WHO guidelines recommend annual treatment for schistosomiasis or soil-transmitted helminthiasis when prevalence in school-aged children is at or above a threshold of 50% and 20%, respectiv
Spatially variable risk factors for malaria in a geographically heterogeneous landscape, western Kenya: an explorative study (Publications)
BACKGROUND: Large reductions in malaria transmission and mortality have been achieved over the last decade, and this has mainly been attributed to the scale-up of long-lasting insecticidal bed nets an
Comparative genomics of drug resistance in<em> Trypanosoma brucei</em> rhodesiense (Publications)
Trypanosoma brucei rhodesiense is one of the causative agents of human sleeping sickness, a fatal disease that is transmitted by tsetse flies and restricted to Sub-Saharan Africa. Here we investigate
Validation of a point-of-care circulating cathodic antigen urine cassette test for <em>Schistosoma mansoni</em> diagnosis in the Sahel, and potential... (Publications)
On the shores of Lake Chad, schistosomiasis among mobile pastoralists was investigated in a field laboratory. Point-of-care circulating cathodic antigen (POC-CCA) cassette test, reagent strips, and fi
Identifying risk factors for <em>Plasmodium </em>infection and anaemia in Kinshasa, Democratic Republic of Congo (Publications)
BACKGROUND: There is little data on the risk factors for malaria infection in large cities in central Africa and in all age groups. There may be different associations with the risk factors for areas
Zika without symptoms in returning travellers: what are the implications (Publications)
Against the background of the emergence and rapid spread of Zika virus (ZIKV) in the Americas, we report the case of an afebrile ZIKV infection in a traveller returning from Central America to highlig
Pharmacokinetic study of praziquantel enantiomers and its main metabolite R-trans-4-OH-PZQ in plasma, blood and dried blood spots in <em>Opisthorchis... (Publications)
BACKGROUND: Praziquantel (PZQ) is the treatment of choice for infections with the liver fluke Opisthorchis viverrini, a major health problem in Southeast Asia. However, pharmacokinetic (PK) studies in
Miltefosine for mucosal and complicated cutaneous old world leishmaniasis: a case series and review of the literature (Publications)
Complicated Old World cutaneous leishmaniasis (OWCL) and Old World mucosal leishmaniasis (OWML) constitute an indication for systemic treatment. To date, there no controlled clinical studies that comp
