Potent antimalarial 1,2,4-trioxanes through perhydrolysis of epoxides (Publications)
Perhydrolysis of a sterically congested multifunctional epoxide was achieved in ethereal H2 O2 with the aid of a recently developed Mo catalyst. The resulting hydroperoxide cyclized to give a 1,2,4-tr
<em>Mycobacterium tuberculosis</em> mutation rate estimates from different lineages predict substantial differences in the emergence of drug-resistant... (Publications)
A key question in tuberculosis control is why some strains of M. tuberculosis are preferentially associated with resistance to multiple drugs. We demonstrate that M. tuberculosis strains from lineage
Synthesis and antiprotozoal activities of benzyl phenyl ether diamidine derivatives (Publications)
Sixty-two cationic benzyl phenyl ether derivatives (36 amidines and 26 prodrugs) were prepared and assayed for activities in vitro and in vivo against Trypanosoma brucei rhodesiense (STIB900), and in
Novel 3-nitro-1<em>H</em>-1,2,4-triazole-based piperazines a nd 2-amino-1,3-benzothiazoles as antichagasic agents (Publications)
We have previously shown that 3-nitro-1H-1,2,4-triazole-based amines demonstrate significant trypanocidal activity, in particular against Trypanosoma cruzi, the causative parasite of Chagas disease. I
Nonrandomized controlled trial of artesunate plus sulfadoxine-pyrimethamine with or without primaquine for preventing posttreatment circulation of... (Publications)
Artemisinin combination therapies eliminate immature Plasmodium falciparum gametocytes but not mature gametocytes, which may persist for up to 1 month posttreatment. A single dose of primaquine, which
UV-triggered affinity-capture identifies interactions between the <em>Plasmodium falciparum</em> multidrug resistance protein 1 (PfMDR1) and... (Publications)
A representative of a new class of potent antimalarials with an unknown mode of action was recently described. To identify the molecular target of this class of antimalarials, we employed a photo-reac
Schistosomiasis research in Africa: how the CONTRAST alliance made it happen (Publications)
In May 2012, the World Health Assembly passed resolution WHA 65.21, calling upon member states to intensify schistosomiasis control and, wherever possible, to attempt transmission interruption and ini