CRISPR-Cas9-modified <em>pfmdr1</em> protects <em>Plasmodium falciparum </em>asexual blood stages and gametocytes against a class of... (Publications)
Emerging resistance to first-line antimalarial combination therapies threatens malaria treatment and the global elimination campaign. Improved therapeutic strategies are required to protect existing d
Antibody-mediated neutralization of the exotoxin mycolactone, the main virulence factor produced by <em>Mycobacterium ulcerans</em> (Publications)
BACKGROUND: Mycolactone, the macrolide exotoxin produced by Mycobacterium ulcerans, causes extensive tissue destruction by inducing apoptosis of host cells. In this study, we aimed at the production o
Inhibition of <em>Plasmodium falciparum</em> Hsp90 contributes to the antimalarial activities of aminoalcohol-carbazoles (Publications)
Malaria caused by the protozoan parasite Plasmodium falciparum (Pf) remains a major public health problem throughout the developing world. One molecular target that should receive more attention is th
Non-vector-borne transmission of Zika virus: a systematic review (Publications)
BACKGROUND: Increasing numbers of confirmed cases of Zika virus (ZIKV) infection resulting from non-mosquito-borne transmission have been reported. METHODS: We performed a systematic literature review
Single ascending dose pharmacokinetic study of tribendimidine in <em>Opisthorchis viverrini</em>-infected patients (Publications)
OBJECTIVES: Praziquantel is the only drug available for treatment of Opisthorchis viverrini infections. Tribendimidine has emerged as potential treatment alternative, however its pharmacokinetic (PK)
Nitrotriazole-based acetamides and propanamides with broad spectrum antitrypanosomal activity (Publications)
3-Nitro-1H-1,2,4-triazole-based acetamides bearing a biphenyl- or a phenoxyphenyl moiety have shown remarkable antichagasic activity both in vitro and in an acute murine model, as well as substantial
Community co-designed schistosomiasis control interventions for school-aged children in Zanzibar (Publications)
Top-down biomedical interventions to control schistosomiasis in sub-Saharan Africa have had limited success, primarily because they fail to engage with the social, political, economic and ecological c
Should viral load thresholds be lowered? Revisiting the WHO definition for virologic failure in patients on antiretroviral therapy in resource-limited... (Publications)
The World Health Organization (WHO) guidelines on antiretroviral therapy (ART) define treatment failure as 2 consecutive viral loads (VLs) > /=1000 copies/mL. There is, however, little evidence suppor
The antiprotozoal potencies of newly prepared 3-azabicyclo[3.2.2]nonanes (Publications)
3-Azabicyclo[3.2.2]nonanes are already reported as antiprotozoal agents. Structural variations were performed by attachment of several basic side chains, being part of drugs in use, to the ring nitrog
