Efficacy and safety of a fixed-dose oral combination of pyronaridine-artesunate compared with artemether-lumefantrine in children and adults with... (Publications)
uncomplicated falciparum malaria. Pyronaridine-artesunate should be considered for inclusion in malaria treatment programmes. FUNDING: Shin Poong Pharmaceutical and the Medicines for Malaria Venture. [...] pyronaridine-artesunate with that of artemether-lumefantrine for treatment of uncomplicated P falciparum malaria. METHODS: This phase 3, parallel-group, double-blind, randomised, non-inferiority trial was undertaken [...] southeast Asia. In a double-dummy design, patients aged 3-60 years with...
The synthetic<em> Plasmodium falciparum</em> circumsporozoite peptide PfCS102 as a malaria vaccine candidate: a randomized controlled phase I trial (Publications)
Plasmodium falciparum circumsporozoite protein (PfCS102) in malaria naive adults. METHODOLOGY AND PRINCIPAL FINDINGS: Thirty-six healthy malaria-naive adults were randomly distributed into three dose blocks [...] BACKGROUND: Fully efficient vaccines against malaria pre-erythrocytic stage are still lacking. The objective of this dose/adjuvant-finding study was to evaluate the safety, reactogenicity and immunogenicity
The architecture and effect of participation: a systematic review of community participation for communicable disease control and elimination.... (Publications)
successful disease control and elimination campaigns in many countries. Despite this, its benefits for malaria control and elimination are yet to be fully realized. This may be due to a limited understanding [...] participation for communicable disease control and elimination and provide guidance for the current malaria elimination campaign. METHODS: Evidence derived from quantitative research was considered both i [...] communicable disease control and elimination which is presented herein....
Effectiveness of combined intermittent preventive treatment for children and timely home treatment for malaria control (Publications)
awaiting for the arrival of an effective and affordable malaria vaccine, there is a need to make use of the available control tools to reduce malaria risk, especially in children under five years and pregnant [...] important component of the malaria control strategy. This study explored the potential of a strategy of intermittent preventive treatment for children (IPTC) and timely treatment of malaria-related febrile illness [...] of febrile malaria illness, impacts significantly on the parasite...
The low and declining risk of malaria in travellers to Latin America: is there still an indication for chemoprophylaxis? (Publications)
was made between local malaria transmission and malaria imported by travellers to identify the utility of national and regional annual parasite index (API) in predicting malaria risk and its value in [...] generating recommendations on malaria prophylaxis for travellers.Regional malaria transmission data was correlated with malaria acquired in Latin America and imported into the USA and nine European countries [...] countries reported declining malaria transmission. Highest API's in 2003/4 were...
Malaria prophylaxis policy for travellers from Europe to the Indian subcontinent (Publications)
countries was only 23 (13% of all cases from the region). Total malaria reports between 1999-2004 fell from 317 to 180. The risk of malaria in UK residents visiting the region was > 1 case per 1,000 years [...] Analysis of malaria imported into eight European countries from the Indian Sub-continent (ISC) (India, Pakistan, Bangladesh and Sri Lanka) led to a consensus statement on the use of chemoprophylaxis within
A long-duration dihydroorotate dehydrogenase inhibitor (DSM265) for prevention and treatment of malaria (Publications)
Malaria is one of the most significant causes of childhood mortality, but disease control efforts are threatened by resistance of the Plasmodium parasite to current therapies. Continued progress in combating [...] combating malaria requires development of new, easy to administer drug combinations with broad-ranging activity against all manifestations of the disease. DSM265, a triazolopyrimidine-based inhibitor of [...] dehydrogenase (DHODH), is the first DHODH inhibitor to reach clinical...