Residual antimalarial concentrations before treatment in patients with malaria from Cambodia: indication of drug pressure (Publications)
at reducing inappropriate drug use. Methods. Baseline samples from 125 patients with falciparum malaria recruited for 2 in vivo studies (in Preah Vihear and Pursat provinces) were analyzed for the presence [...] (25% and 35% of patients) and piperaquine (15% of patients); the first-line drug against vivax malaria, chloroquine (25% and 41% of patients); and the former first-line drug, quinine (5% and 34% patients)
Methotrexate and aminopterin lack in vivo antimalarial activity against murine malaria species (Publications)
rheumatoid arthritis indicates that it could be safe and efficacious for treating malaria. We sought to establish a murine malaria model to study the mechanism of action and resistance of MTX and its analogue [...] receptor/transport to gain access to cells, their lack of efficacy against the four tested murine malaria species may be the result of inefficiency of drug transport
Synthetic GPI array to study antitoxic malaria response (Publications)
Parasite glycosylphosphatidylinositol (GPI) is an important toxin in malaria disease, and people living in malaria-endemic regions often produce high levels of anti-GPI antibodies. The natural anti-GPI [...] on a synthetic GPI glycan array to correlate anti-GPI antibody levels and protection from severe malaria
Differential var gene expression in children with malaria and antidromic effects on host gene expression (Publications)
Among 62 children with mild malaria, cerebral malaria, or severe malarial anemia, we analyzed the transcription of different var gene types. There was no difference in parasitemia level or body temperature [...] expression pattern was observed in children with cerebral malaria, compared with that in patients in the other 2 groups: children with cerebral malaria had lower expression of the upsA subtype but higher expression
Pan-African Training School on Mathematical Modelling of Infectious Diseases (Malaria) (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/pan-african-training-school-on-mathematical-modelling-of-infectious-diseases-malaria
infectious diseases, focusing on Malaria, at the Center of Epidemiological and Modelling Analysis (CEMA), Nairobi, Kenya. This two-week event will host 15 participants from malaria-endemic African countries and [...] epidemiology, and data science. The course will cover infectious disease modelling theory, specifically malaria, and provide hands-on experience with R programming and model simulations. Participants will apply [...] through guided projects applicable to their specific areas of...