Characterization of field malaria isolates and assessment of the impact of resistance profile on the transmission of resistant strains (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/characterization-of-field-malaria-isolates-and-assessment-of-the-impact-of-resistance-profile-on-the-transmission-of-resistant-strains
field malaria parasites, in order to provide a more realistic representation of malaria transmission occurring in natural settings. We will establish a continuous culture protocol for field malaria parasite [...] Health Institute (IHI, Tanzania). Malaria elimination is threatened by resistance to current insecticides and antimalarials. Developing novel technologies that target malaria transmission, such as transmission [...] transmission blocking drugs, vaccines or insecticides to control malari...
Provision of a Scoping Study for a Strategic Environmental Assessment (SEA) on behalf of Target Malaria (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/provision-of-a-scoping-study-for-a-strategic-environmental-assessment-sea-on-behalf-of-target-malaria
Genetically modified mosquitoes represent great potential for malaria control. Any future application of gene drive mosquitoes for malaria control will require many elements, including policy action, [...] to suppress populations of malaria vector mosquitoes. The assessments main objectives are to: (i) raise awareness amongst policy makers of genetic control tools for malaria using gene drives (ii) develop [...] gene drive (the action) and subsequent reduction of malaria (the desired effect)...
Spatio-temporal modelling to assess the impact of climate change on the burden of malaria and to support early warning systems (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/spatio-temporal-modelling-to-assess-the-impact-of-climate-change-on-the-burden-of-malaria-and-to-support-early-warning-systems
climate variability, land use, malaria vector control coverage and socio-economic factors to changes in malaria incidence and mortality; (ii) develop stochastic metapopulation malaria transmission models which [...] statistical models to forecast malaria; (iv) evaluate the effects of environmental vector-control with microbial larvicides on the burden of malaria; and (v) project future malaria burden based on scenarios [...] changes, malaria interventions and socioeconomic effects, which are...
Mathematical models to define new malaria immunotherapies and interventions to meet public health needs (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/mathematical-models-to-define-new-malaria-immunotherapies-and-interventions-to-meet-public-health-needs
progress in fighting malaria, there remains a need for new antimalarial interventions to protect children and other vulnerable populations who experience the highest burden of malaria. Developing new in [...] from academia, product development partners, and representatives from malaria-endemic countries. Our focus is on next-generation malaria vaccines, monoclonal antibodies, and new chemoprevention antimalarials
Modelling support to decision-making for malaria control in Benin (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/modelling-support-to-decision-making-for-malaria-control-in-benin
interact with the NMCP to gather a deeper understanding of the past malaria burden and control efforts. We then calibrate OpenMalaria , the malaria transmission simulation platform developed in-house, to quantify [...] National Malaria Control Program (NMCP) since 2018. The NMCP is currently updating its National Strategic Plan (NSP) for the period 2024-2026. This plan will guide the strategy and tools for malaria control [...] more impactful between administering seasonal malaria...
Deciphering Environmental Sensing in Malaria Parasites (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/deciphering-environmental-sensing-in-malaria-parasites
The Malaria Host Interactions Unit (MHIU) is studying the molecular interface between malaria parasites and their human host. Recent findings revealed the existence of intimate links between parasite [...] inducing specific transcriptional responses. This capability is surprising in light of the fact that malaria parasites have lost canonical nutrient sensing pathways present in other eukaryotic organisms. With
NETCELL Phase 5 - Core support to the National Malaria Control Programme in Tanzania (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/netcell-phase-5-core-support-to-the-national-malaria-control-programme-in-tanzania
Since its inception in 2002 the NETCELL Project has played a key role in supporting the National Malaria Control Programme (NMCP) of the Tanzanian Ministry of Health and Social Welfare, by managing the [...] Insecticide Treated Net (NATNETS) Programme. Over 200 million dollars of international donor funding for malaria prevention have been leveraged for the MoHSW in the past decade, and the NATNETS programme has been [...] focus on technical advice and strategic support; 2) an extension of...
Core Malaria Modelling (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/core-malaria-modelling
and use of an individual-based model of malaria transmission dynamics known as OpenMalaria. This model is an open-source tool for simulating the dynamics of malaria transmission and epidemiology, and the [...] and economic outcomes. The opensource code and details of our model OpenMalaria can be found here . The model can simulate malaria in village or district size human populations, and has been used to address [...] TPH, our OpenMalaria model is used by a wide range of modellers worldwide....
Towards Elimination of Malaria in Tanzania (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/towards-elimination-of-malaria-in-tanzania
Malaria and poverty entertain a close relationship through historical times. Past studies have abundantly documented the benefits of malaria control on economic development and human well-being, and as [...] of malaria across the country declined, the heterogeneity in transmission greatly increased. At present, some areas in Tanzania remain with a very high transmission and hence with a high malaria burden [...] and risk stratification followed by decentralized malaria control planning has...