A research agenda to underpin malaria eradication (Publications)
could be achieved against malaria, including elimination from a number of countries and regions; however, even with maximal effort we will fall short of global eradication. The Malaria Eradication Research [...] The interruption of malaria transmission worldwide is one of the greatest challenges for international health and development communities. The current expert view suggests that, by aggressively scaling
Monitoring of malaria parasite resistance to chloroquine and sulphadoxine-pyrimethamine in the Solomon Islands by DNA microarray technology (Publications)
the SI in 2004. Patients presenting at a local clinic with microscopically confirmed P. falciparum malaria were recruited and treated with CQ+SP. Rates of treatment failure were estimated during a 28-day
Community concepts of malaria-related illness with and without convulsions in southern Ghana (Publications)
BACKGROUND: Malaria, both with or without convulsions, is a serious hardship for people living in endemic areas, especially in sub-Saharan Africa. Community references to malaria, however, may encompass [...] which was collectively designated malaria-related illness (MRI). Inasmuch as the presence or absence of convulsions reportedly affects timely help-seeking for malaria, a local comparison of these conditions [...] conditions is needed to inform malaria control. METHODS: Vignette-based EMIC...
Malaria prophylaxis policy for travellers from Europe to the Indian subcontinent (Publications)
countries was only 23 (13% of all cases from the region). Total malaria reports between 1999-2004 fell from 317 to 180. The risk of malaria in UK residents visiting the region was > 1 case per 1,000 years [...] Analysis of malaria imported into eight European countries from the Indian Sub-continent (ISC) (India, Pakistan, Bangladesh and Sri Lanka) led to a consensus statement on the use of chemoprophylaxis within
The low and declining risk of malaria in travellers to Latin America: is there still an indication for chemoprophylaxis? (Publications)
was made between local malaria transmission and malaria imported by travellers to identify the utility of national and regional annual parasite index (API) in predicting malaria risk and its value in [...] generating recommendations on malaria prophylaxis for travellers.Regional malaria transmission data was correlated with malaria acquired in Latin America and imported into the USA and nine European countries [...] countries reported declining malaria transmission. Highest API's in 2003/4 were...
Assessing the impact of next-generation rapid diagnostic tests on <em>Plasmodium falciparum</em> malaria elimination strategies (Publications)
n strategies are being considered as a means to interrupt transmission of Plasmodium falciparum malaria. However, the effectiveness of such strategies will depend on the extent to which current and future
Gift from nature: cyclomarin a kills mycobacteria and malaria parasites by distinct modes of action (Publications)
Malaria continues to be one of the most devastating human diseases despite many efforts to limit its spread by prevention of infection or by pharmaceutical treatment of patients. We have conducted a screen [...] enzymesubstrate complex. These results validate PfAp3Aase as a new drug target for the treatment of malaria. We have previously elucidated the structurally unrelated regulatory subunit ClpC1 of the ClpP protease
Progress with <em>Plasmodium falciparum </em>sporozoite (PfSPZ)-based malaria vaccines (Publications)
injectable PfSPZ-based vaccine that provides high grade, durable protection against infection with Pf malaria. Several candidate vaccines are being developed and tested, including PfSPZ Vaccine, in which the [...] and long-term objectives for a final product suitable for mass administration to achieve regional malaria elimination and eventual global eradication
The effect of malaria control on <em>Plasmodium falciparum</em> in Africa between 2000 and 2015 (Publications)
database of malaria field surveys with detailed reconstructions of changing intervention coverage to directly evaluate trends from 2000 to 2015, and quantify the attributable effect of malaria disease control [...] contributor (68% of cases averted). Although still below target levels, current malaria interventions have substantially reduced malaria disease incidence across the continent. Increasing access to these interventions [...] Since the year 2000, a concerted campaign against malaria has...