Prevalence of malaria across Papua New Guinea after initial roll-out of insecticide-treated mosquito nets (Publications)
samples were collected from all consenting household members for microscopic diagnosis of malaria. RESULTS: Malaria prevalence ranged from 0% to 49.7% with a weighted average of 12.1% (95% CI 9.5, 15.3) in [...] 0.001). Splenomegaly in children and anaemia were common morbidities attributable to malaria. CONCLUSIONS: Malaria prevalence across PNG is again at levels comparable to the 1970s. The strong association [...] OBJECTIVES: To assess the population prevalence of malaria in villages across...
Assessing the impact of next-generation rapid diagnostic tests on <em>Plasmodium falciparum</em> malaria elimination strategies (Publications)
n strategies are being considered as a means to interrupt transmission of Plasmodium falciparum malaria. However, the effectiveness of such strategies will depend on the extent to which current and future
Giant host red blood cell membrane mimicking polymersomes bind parasite proteins and malaria parasites (Publications)
we aim for a dual action with drug- and 'vaccine-like' activity against malaria. By inhibiting entry of malaria parasites into host red blood cells (RBCs) - using polymer vesicle-based (polymersome) nanomimics [...] formed with the same block copolymers as nanomimics, also bind the corresponding malaria parasite ligand and whole malaria parasites, similar to nanomimics. This was demonstrated using fluorescence imaging [...] Malaria is an infectious disease that needs to be addressed using...
Cluster-randomized study of Intermittent Preventive Treatment for malaria in infants (IPTi) in southern Tanzania: evaluation of impact on survival (Publications)
BACKGROUND: Intermittent Preventive Treatment for malaria control in infants (IPTi) consists of the administration of a treatment dose of an anti-malarial drug, usually sulphadoxine-pyrimethamine, at scheduled
Prices and mark-ups on antimalarials: evidence from nationally representative studies in six malaria-endemic countries (Publications)
sector is an important source of treatment for malaria. However, private patients face high prices for the recommended treatment for uncomplicated malaria, artemisinin combination therapies (ACTs), which
Defining the relationship between infection prevalence and clinical incidence of<em> Plasmodium falciparum</em> malaria (Publications)
falciparum malaria cases. In response, cartographic approaches have been developed that link maps of infection prevalence with mathematical relationships to predict the incidence rate of clinical malaria. Mi
Genetic diversity and protective efficacy of the RTS,S/AS01 malaria vaccine (Publications)
clinical malaria in which parasites matched the vaccine in the entire circumsporozoite protein C-terminal (139 infections), as compared with 33.4% (95% CI, 29.3 to 37.2) against mismatched malaria (1951 [...] age, the RTS,S vaccine has greater activity against malaria parasites with the matched circumsporozoite protein allele than against mismatched malaria. The overall vaccine efficacy in this age category [...] protein of Plasmodium falciparum and has partial protective efficacy against...
No fever, no malaria? A diagnostic challenge in an immunocompromised patient (Publications)
women with proven malaria tropicana. Fever was not reported with this patient. We conclude that the concept of using fever as a primary surrogate indicator for the presence of malaria should be used with
