Histone methyltransferase inhibitors are orally bioavailable, fast acting molecules with activity against different species causing malaria in humans (Publications)
antimalarials are under continuous threat due to the relentless development of drug resistance by malaria parasites. We previously reported promising in vitro parasite killing activity with the histone
Acquisition of antibodies against <em>Plasmodium falciparum</em> merozoites and malaria immunity in young children: influence of age, force of... (Publications)
levels were not associated with protection from malaria; in contrast, they were typically associated with an increased risk of malaria. Adjustment for malaria exposure, using a novel molecular measure of [...] subclasses) to merozoite antigens and their relationship to the prospective risk of malaria in children aged 1-4yrs in a malaria endemic region of Papua New Guinea. IgG, IgG1 and IgG3 responses generally increased [...] required for protection from malaria. Our results suggest that in...
Mass screening and treatment on the basis of results of a <em>Plasmodium</em> <em>falciparum</em>-specific rapid diagnostic test did not reduce... (Publications)
reaction (PCR) analyses. Data on confirmed malaria infections from health facilities in intervention and hotspot control areas were monitored as proxy for malaria transmission. RESULTS: Approximately 64% [...] carriers) did not reduce subsequent malaria incidence compared with control areas. CONCLUSIONS: Highly sensitive point-of-care diagnostic tools for detection of all human malaria species are needed to make MSAT [...] BACKGROUND: Seasonal increases in malaria continue in hotspots in...
First results of phase 3 trial of RTS,S/AS01 malaria vaccine in African children (Publications)
vaccination with either RTS,S/AS01 or a non-malaria comparator vaccine. The primary end point of the analysis was vaccine efficacy against clinical malaria during the 12 months after vaccination in the [...] vaccine according to protocol. After 250 children had an episode of severe malaria, we evaluated vaccine efficacy against severe malaria in both age categories. Results In the 14 months after the first dose [...] against severe malaria was 45.1% (95% CI, 23.8 to 60.5) in the...
