Cytochrome P450 6M2 from the malaria vector <em>Anopheles gambiae</em> metabolizes pyrethroids: sequential metabolism of deltamethrin revealed (Publications)
Resistance to pyrethroid insecticides in the malaria vector Anopheles gambiae is a major threat to malaria control programmes. Cytochome P450-mediated detoxification is an important resistance mechanism [...] metabolic resistance to pyrethroids and thus an important target for the design of new tools to combat malaria
Structural and functional characterisation of the toll like receptor 9 of <em>Aotus nancymaae</em>, a non-human primate model for malaria vaccine... (Publications)
In the absence of suitable rodent animal models for Plasmodium falciparum malaria, the efficacy testing of asexual blood-stage vaccine candidates in Aotus nancymaae represents a tool to select between [...] sequence conservation of Aona-TLR-9 reinforces the suitability of A. nancymaae as animal model for malaria subunit vaccine development
The Internet: a valuable tool for Roll Back Malaria (Publications)
Roll Back Malaria (RBM) will face a tremendous challenge in halving the current malaria burden by 2010. Thus, the initiative needs to explore novel and innovative approaches. The potential of the Internet [...] build a virtual community and to facilitate the training of a new generation of skilled personel for malaria diagnosis is discussed here. We also argue that investment in information technology is crucial to
Efficacy and cost-effectiveness of environmental management for malaria control (Publications)
implementation, the programme had averted an estimated 4173 deaths and 161,205 malaria attacks. The estimated costs per death and malaria attack averted were US$ 858 and US$ 22.20, respectively. Over the initial [...] Roll back malaria (RBM) aims at halving the current burden of the disease by the year 2010. The focus is on sub-Saharan Africa, and it is proposed to implement efficacious and cost-effective control strategies [...] of the potential of environmental management. We reviewed the...
<em>Falciparum </em>malaria presenting with pruritic rashes (Publications)
Rash is not generally believed to be a symptom of malaria. Two cases of acute falciparum malaria in non-immune residents of Mozambique who presented with pruritic rashes are reported. One case exhibited [...] Review of the literature reveals cases of malaria from India, East Africa, France, and the USA presenting with urticaria or a pruritic rash. Previous exposure to malaria may be a factor in these presentations [...] ns. Physicians should not discount the diagnosis of malaria in patients with...
Synthetic glycosylphosphatidylinositol microarray reveals differential antibody levels and fine specificities in children with mild and severe malaria (Publications)
Plasmodium falciparum life cycle are a central toxin in malaria. The contribution of GPI specific humoral immune responses to protection against malaria pathology is not clear, since studies on the correlation [...] anti-GPI antibody responses in healthy and malaria diseased individuals. Furthermore, the age dependent development of humoral immune responses against GPI in malaria-exposed children was investigated. Anti-GPI [...] with severe malaria and healthy children contained antibodies that...