Exploring the mechanisms of heritable gene silencing and singular gene choice to understand antigenic variation in malaria parasites (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/exploring-the-mechanisms-of-heritable-gene-silencing-and-singular-gene-choice-to-understand-antigenic-variation-in-malaria-parasites
epigenetic control mechanisms involved in the production of malaria transmission stages and in antigenic variation and immune evasion of malaria parasites. To achieve this we combine molecular and cell biology
Majete Malaria Control Project Monitoring (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/majete-malaria-control-project-monitoring
effect of the malaria control interventions, through the creation of malaria animators and community-based malaria action teams. The project goal is an 80% reduction in incidence of clinical malaria and 50% [...] of malaria control through the epicentre approach • Increase community participation in malaria control • Implement locally-appropriate malaria vector control strategies • Measure impact on malaria [...] Malaria continues to place a heavy burden of disease in southern Malawi. Effective...
Collaboration on Malaria drug discovery (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/collaboration-on-malaria-drug-discovery
The goal of this collaborative project with Actelion Pharmaceuticals is the discovery of new antimalarial molecules with unknown mechanism(s) of action. Cell-based antimalarial screens were performed
Drug discovery for malaria based on novel drug targets in the NGBS Consortium (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/drug-discovery-for-malaria-based-on-novel-drug-targets-in-the-ngbs-consortium
The NGBS programme in malaria drug discovery is a collaboration between the Novartis Institute for Tropical Diseases (NITD), the Genomics Institute of the Novartis Research Foundation (GNF), the Biomedical [...] programme aims at solving two fundamental medical needs. Firstly, a one dose cure for P. falciparum malaria would be a breakthrough in solving compliance problems, and would also contribute easing logistical [...] NITD609 is the first molecule from a novel class of antimalarials to enter...