The effect of mass mosquito trapping on malaria transmission and disease burden (SolarMal): a stepped-wedge cluster-randomised trial (Publications)
clinical malaria episodes were recorded in intervened clusters and 33 episodes in non-intervened clusters (adjusted effectiveness 40.8% [95% CI -172.8 to 87.1], p=0.5) during the roll-out. Malaria prevalence [...] unexpectedly low clinical incidence of malaria during roll-out led to an imprecise estimate of effectiveness from the clinical incidence data. The substantial effect on malaria prevalence is explained by reduction [...] mosquitoes indoors and outdoors. We assessed the effects of mass...
Mass mosquito trapping for malaria control in western Kenya: study protocol for a stepped wedge cluster-randomised trial (Publications)
of malaria threaten the efficacy of existing vector control tools used against malaria mosquitoes. The development of odour-baited mosquito traps has led to the possibility of controlling malaria through [...] mass mosquito trapping could be an effective tool for elimination of malaria. If proven to be effective, this novel approach to malaria control would be a valuable addition to the existing strategies of [...] through mass trapping of malaria vectors. Through daily removal trapping against...
Severe malaria in Europe: an 8-year multi-centre observational study (Publications)
lly confirmed severe Plasmodium falciparum malaria according to the 2006 WHO criteria. RESULTS: From 2006 to 2014 a total of 185 patients with severe malaria treated in 12 European countries were included [...] patients with severe malaria in this study were tourists or migrants acquiring the infection in West Africa. Intravenous artesunate is increasingly used for treatment of severe malaria in many European treatment [...] BACKGROUND: Malaria remains one of the most serious infections for...
Structure of the malaria vaccine candidate antigen CyRPA and its complex with a parasite invasion inhibitory antibody (Publications)
Invasion of erythrocytes by Plasmodial merozoites is a composite process involving the interplay of several proteins. Among them, the Plasmodium falciparum Cysteine-Rich Protective Antigen (PfCyRPA) i
Malaria intervention scale-up in Africa: effectiveness predictions for health programme planning tools, based on dynamic transmission modelling (Publications)
(IRS), management of uncomplicated malaria cases (CM) and seasonal malaria chemoprophylaxis (SMC) over a 10-year horizon, over a range of settings with stable endemic malaria. Generalized linear regression [...] intervention impact, to inform a malaria module in the Spectrum health programme planning tool. METHODS: The dynamic Plasmodium falciparum transmission model OpenMalaria was used to simulate health effects [...] entail a partial rebound in malaria mortality among people above 5 years of...
Community-based surveillance to monitor mortality in a malaria-endemic and Ebola-epidemic setting in rural Guinea (Publications)
a reinforced malaria control program and one sous-prefecture without (Koundou) in Guinea. Deaths were recorded by key informants and classified as due to malaria or another cause. Malaria deaths were those [...] deaths were reported from July 2011-June 2014, of which 55.2% (N = 686) were reported as due to malaria. Malaria-attributable proportional mortality decreased by 26.5% (95% confidence interval [CI] = 13.9-33 [...] those reported as due to malaria or fever in the 3 days before death with...
Public health impact and cost-effectiveness of the RTS,S/AS01 malaria vaccine: a systematic comparison of predictions from four mathematical models (Publications)
BACKGROUND: The phase 3 trial of the RTS,S/AS01 malaria vaccine candidate showed modest efficacy of the vaccine against Plasmodium falciparum malaria, but was not powered to assess mortality endpoints [...] settings. Decisions about implementation will need to consider levels of malaria burden, the cost-effectiveness and coverage of other malaria interventions, health priorities, financing, and the capacity of the [...] iveness of routine use of the RTS,S/AS01 vaccine in African settings....
