Sporozoite immunization: innovative translational science to support the fight against malaria (Publications)
'sporozoites,' 'malaria,' and 'vaccines.' EXPERT OPINION: First generation (radiation-attenuated) PfSPZ vaccines are safe, well tolerated, 80-100% efficacious against homologous controlled human malaria infection [...] INTRODUCTION: Malaria, a devastating febrile illness caused by protozoan parasites, sickened 247,000,000 people in 2021 and killed 619,000, mostly children and pregnant women in sub-Saharan Africa. A highly [...] effective vaccine is urgently needed, especially for Plasmodium...
Diagnostic de malaria chez le praticien: comment gérer (Publications)
Malaria is the disease to exclude when dealing with a patient coming back from an endemic area with fever. We need reliable diagnostic tools with negative likelihood ratio (LR-) close to zero (-> high [...] 08 (estimated in a meta-analysis of RDT in non-immune travelers), the probability of falciparum malaria is 1% after a negative RDT. When the RDT is positive, the patient should always be treated with an
Meta-analysis: accuracy of rapid tests for malaria in travelers returning from endemic areas (Publications)
PURPOSE: To determine the accuracy of rapid diagnostic tests for ruling out malaria in nonimmune travelers returning from malaria-endemic areas. DATA SOURCES: The authors searched MEDLINE, EMBASE, CAB Health [...] diagnosis of P. malariae or P. ovale were close to 1.0 for both types of tests. In febrile travelers returning from sub-Saharan Africa, the typical probability of P. falciparum malaria is estimated at [...] of rapid diagnostic tests improves outcomes in returning travelers with...
Starting at the community: treatment seeking pathways of children with suspected severe malaria in Uganda (Publications)
five years with suspected severe malaria. Methods: An observational study in Uganda enrolled children below five years presenting to CHWs with signs of severe malaria. Children were followed up 28 days [...] Introduction: Community health workers (CHW) usually refer children with suspected severe malaria to the nearest public health facility or a designated public referral health facility (RHF). Caregivers
PATH Malaria Vaccine Modelling (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/path-malaria-vaccine-modelling
RTS,S/AS01 (RTS,S) is the world’s first malaria vaccine shown to provide partial protection against malaria in young children. In October 2021, WHO recommended widespread use of RTS,S among children in [...] in regions with moderate to high P. falciparum malaria transmission. This recommendation is based on a Phase 3 trial completed in Africa in 2015 and the implementation programme in Ghana, Kenya, and Malawi [...] we provided modelling evidence to support this recommendation and continued to...
World Malaria Day 2024: Work together and accelerate the fight! (Blog)
https://www.swisstph.ch/en/impact-stories/world-malaria-day-2024-work-together-and-accelerate-the-fight/blog-id/81
In the recent past, progress to curb malaria have been stalling. In 2022, over 600,000 people died from malaria, primarily children under the age of 5 years in sub-Saharan Africa. People living in the [...] it is indispensable that the global community stands together and accelerates the fight against malaria for a more equitable world where nobody is left behind.
“It is a privilege to be able to bring science to the bedside” – Elisabeth Reus on the launch of a new malaria clinical trial in the DRC (Blog)
https://www.swisstph.ch/en/impact-stories/it-is-a-privilege-to-be-able-to-bring-science-to-the-bedside/blog-id/83
Elisabeth Reus, Head of the Clinical Operations unit at Swiss TPH, is currently in the Democratic Republic of the Congo (DRC) to launch the phase IIb trial of a new antimalarial drug in collaboration