A phase 3 trial of RTS,S/AS01 malaria vaccine in African infants (Publications)
Background The candidate malaria vaccine RTS,S/AS01 reduced episodes of both clinical and severe malaria in children 5 to 17 months of age by approximately 50% in an ongoing phase 3 trial. We studied infants [...] only episode of clinical malaria during the 12 months after vaccination, a coprimary end point, was analyzed with the use of Cox regression. Vaccine efficacy against all malaria episodes, vaccine efficacy [...] efficacy against severe malaria, safety, and immunogenicity were also...
Use and misuse of a discount voucher scheme as a subsidy for insecticide-treated nets for malaria control in southern Tanzania (Publications)
Since 1997, discount vouchers for insecticide-treated nets (ITNs) have been used in two rural districts of southern Tanzania as a way to target subsidies to children under 5 years and pregnant women.
The economic payoffs of integrated malaria control in the Zambian copperbelt between 1930 and 1950 (Publications)
suggested that malaria is delaying the economic development of countries that are most severely affected by the disease. Several studies have documented the economic consequences of malaria at the household [...] economic impact of malaria on the industrial and service sectors that will probably become the backbone of many developing economies. We estimate the economic effects of integrated malaria control implemented [...] 284 malaria attacks and 942,347 work shift losses were averted. Overall,...
Cost savings with rapid diagnostic tests for malaria in low-transmission areas: evidence from Dar es Salaam, Tanzania (Publications)
Rapid diagnostic tests (RDTs) for malaria may help rationalize antimalarial drug use. However, the economic effects of these tests may vary. Data on costs were collected from 259 patients in 6 health
A <em>var</em> gene promoter controls allelic exclusion of virulence genes in <em>Plasmodium falciparum</em> malaria (Publications)
proteins. In the apicomplexan parasite Plasmodium falciparum, responsible for the severe form of malaria in humans, this is exemplified by antigenic variation of the highly polymorphic P. falciparum erythrocyte
Malaria vectors and their blood-meal sources in an area of high bed net ownership in the western Kenya highlands (Publications)
BACKGROUND: Blood-meal sources of malaria vectors affect their capacity to transmit the disease. Most efficient malaria vectors prefer human hosts. However, with increasing personal protection measures [...] measures it becomes more difficult for them to find human hosts. Here recent malaria vector blood-meal sources in western Kenya highlands were investigated. METHODS: Adult mosquitoes resting indoors, outdoors [...] domesticated animals and 83.6 % had people sharing houses with livestock at...