Organellar proteomics reveals hundreds of novel nuclear proteins in the malaria parasite <em>Plasmodium falciparum</em> (Publications)
BACKGROUND: The post-genomic era of malaria research provided unprecedented insights into the biology of Plasmodium parasites. Due to the large evolutionary distance to model eukaryotes, however, we lack [...] serve as an important platform for dissecting general and parasite-specific nuclear processes in malaria parasites. Moreover, as the first nuclear proteome characterized in any protist organism, it will
Understanding private sector antimalarial distribution chains: a cross-sectional mixed methods study in six malaria-endemic countries (Publications)
BACKGROUND: Private for-profit outlets are important treatment sources for malaria in most endemic countries. However, these outlets constitute only the last link in a chain of businesses that includes
Micro-encapsulated pirimiphos-methyl shows high insecticidal efficacy and long residual activity against pyrethroid-resistant malaria vectors in... (Publications)
e-treated nets and indoor residual spraying (IRS) has contributed to a considerable decrease of malaria morbidity and mortality in sub-Saharan Africa over the last decade. Due to increasing resistance [...] for IRS with long-lasting residual activity are required to sustain the gains obtained in most malaria-endemic countries. METHODS: Three experimental capsule suspension (CS) formulations of the organ [...] alternatives for IRS, as they demonstrate prolonged insecticidal effect and residual...
A household randomized, controlled trial of the efficacy of 0.03% transfluthrin coils alone and in combination with long-lasting insecticidal nets on... (Publications)
evidence that burning mosquito coils prevents malaria acquisition. Therefore, the current trial was designed to measure and compare prevention of malaria infection by mosquito coils or long-lasting in [...] members that regularly slept away from home. The main outcome of interest was Plasmodium falciparum malaria prevalence detected by rapid diagnostic tests (RDTs) during six repeated monthly cross-sectional [...] This is the first robust clinical evaluation of transfluthrin mosquito coils as a...
Community-owned resource persons for malaria vector control: enabling factors and challenges in an operational programme in Dar es Salaam, United... (Publications)
remains complex and poorly understood. The Urban Malaria Control Program (UMCP) in Dar es Salaam, United Republic of Tanzania, implements larval control of malaria vector mosquitoes. The UMCP delegates resp
Seasonally dependent relationships between Indicators of malaria transmission and disease provided by mathematical model simulations (Publications)
levels of malaria transmission, patterns of seasonality and access to treatment were run with an ensemble of models of malaria epidemiology and within-host dynamics, as part of the OpenMalaria modeling [...] relationships between malaria indicators allowing more easily measured data, such as routine health systems data on case incidence, to be translated into measures of transmission and other malaria indicators. [...] previously published data on these same indicators as observed in malaria...
Comparative field evaluation of the Mbita trap, the Centers for Disease Control light trap, and the human landing catch for sampling of malaria... (Publications)
to the sampling method used. It is concluded that the Mbita trap is a promising tool for sampling malaria vector populations since its catch can be readily converted into equivalent human biting catch, it [...] exposure-free manner. Such intensive sampling capability will allow cost-effective surveillance of malaria transmission at much finer spatial and temporal resolution than has been previously possible