Safety, immunogenicity, and protective efficacy against controlled human malaria infection of<em> Plasmodium falciparum</em> sporozoites vaccine in... (Publications)
We are using controlled human malaria infection (CHMI) by direct venous inoculation (DVI) of cryopreserved, infectious Plasmodium falciparum (Pf) sporozoites (SPZ) (PfSPZ Challenge) to try to reduce time [...] time and costs of developing PfSPZ Vaccine to prevent malaria in Africa. Immunization with five doses at 0, 4, 8, 12, and 20 weeks of 2.7 x 10(5) PfSPZ of PfSPZ Vaccine gave 65% vaccine efficacy (VE) at [...] and controls. Antibody responses to Pf circumsporozoite protein were...
UCT943, a next generation <em>Plasmodium falciparum</em> PI4K inhibitor preclinical candidate for the treatment of malaria (Publications)
drug candidate inhibiting Plasmodium phosphatidylinositol 4-kinase (PI4K), a novel drug target for malaria, to enter clinical development. In an effort to identify the next generation of PI4K inhibitors, [...] single-exposure radical cure and prophylaxis (SERCaP) to treat, prevent and block the transmission of malaria.
Malaria and the 'last' parasite: how can technology help? (Publications)
Malaria, together with HIV/AIDS, tuberculosis and hepatitis are the four most deadly infectious diseases globally. Progress in eliminating malaria has saved millions of lives, but also creates new challenges [...] accurate detection of malaria infections, both in symptomatic and asymptomatic individuals are needed. In this review, the current progress in developing new diagnostic tools to fight malaria is presented. An [...] An ideal rapid test for malaria elimination is envisioned with examples...
Modelling the relationship between malaria prevalence as a measure of transmission and mortality across age groups (Publications)
prevalence has been used widely as a measure of malaria transmission, especially in malaria endemic areas. However, its contribution and relationship to malaria mortality across different age groups has not [...] all-cause and malaria-specific mortality. CONCLUSION: Malaria parasitaemia from cross-sectional surveys was associated with mortality across age groups over 4 to 5 year periods with clinical malaria more strongly [...] surveys from the Kisumu HDSS between 2007 and 2015 were used to...
Modelling reactive case detection strategies for interrupting transmission of <em>Plasmodium falciparum</em> malaria (Publications)
BACKGROUND: As areas move closer to malaria elimination, a combination of limited resources and increasing heterogeneity in case distribution and transmission favour a shift to targeted reactive interventions [...] strategies vary, and it is unclear which are most effective in achieving elimination. METHODS: OpenMalaria, an established individual-based stochastic model, was used to simulate RCD in a Zambia-like setting