PCR correction strategies for malaria drug trials: updates and clarifications (Publications)
Malaria drug trials conducted in endemic areas face a major challenge in their analysis because it is difficult to establish whether parasitaemia in blood samples collected after treatment indicate drug [...] public and private bodies who are working on the development, deployment, and surveillance of new malaria drugs. We aim to promote discussion around these issues and argue for the adoption of improved s
Multiplicity of asymptomatic <em>Plasmodium falciparum </em>infections and risk of clinical malaria: a systematic review and pooled analysis of... (Publications)
subsequent febrile malaria or with an increased risk. CONCLUSIONS: The number of clones in asymptomatic P. falciparum infections is associated with different risks of subsequent clinical malaria depending on [...] BACKGROUND: The malaria parasite Plasmodium falciparum holds an extensive genetic polymorphism. In this pooled analysis, we investigate how the multiplicity, i.e. the number of co-infecting clones, in [...] in asymptomatic P. falciparum infections affects the subsequent risk of...
Effects of climate variability on malaria transmission in southern Côte d'Ivoire, West Africa (Publications)
variables and malaria transmission in Côte d’Ivoire. We used the VECTRI model to predict malaria transmission in southern Côte d’Ivoire. First, we tested the suitability of VECTRI in modeling malaria transmission [...] Malaria continues to be a major public health concern with a substantial burden in Africa. Even though it has been widely demonstrated that malaria transmission is climate-driven, there have been very [...] rate (EIR) from the VECTRI model was well correlated with the observed mal...
Sporozoite immunization: innovative translational science to support the fight against malaria (Publications)
'sporozoites,' 'malaria,' and 'vaccines.' EXPERT OPINION: First generation (radiation-attenuated) PfSPZ vaccines are safe, well tolerated, 80-100% efficacious against homologous controlled human malaria infection [...] INTRODUCTION: Malaria, a devastating febrile illness caused by protozoan parasites, sickened 247,000,000 people in 2021 and killed 619,000, mostly children and pregnant women in sub-Saharan Africa. A highly [...] effective vaccine is urgently needed, especially for Plasmodium...
Assessing caregivers' perceptions of treatment-seeking for suspected severe malaria in the Democratic Republic of the Congo (Publications)
BACKGROUND: Malaria remains a major public health issue in the Democratic Republic of the Congo (DRC), accounting for 44% deaths among outpatient visits in children
Rift Valley fever and malaria co-infection: a case report (Publications)
case of febrile illness that confirmed to be a co-infection of malaria and Rift Valley fever. The patient was initially diagnosed with malaria and started on treatment immediately. However, due to the lack [...] febrile illness that was presented with mild symptoms. However, laboratory investigation confirmed a malaria and Rift Valley fever co-infection. Healthcare providers in settings endemic with several infectious
Tafenoquine following G6PD screening versus primaquine for the treatment of vivax malaria in Brazil: a cost-effectiveness analysis using a... (Publications)
most sensitive to severity and mortality due to vivax malaria, the lifetime and number of semiquantitative G6PD analysers needed, cost per malaria episode and per G6PD test strips, and life expectancy [...] BACKGROUND: Malaria transmission modelling has demonstrated the potential impact of semiquantitative glucose-6-phosphate dehydrogenase (G6PD) testing and treatment with single-dose tafenoquine for Plasmodium [...] estimates for low transmission settings, the costs of G6PD screening, and the...
Bridging the gap from molecular surveillance to programmatic decisions for malaria control and elimination (Publications)
An increasing number of molecular and genomic assays are available to study malaria parasite populations. However, so far they have played a marginal role in informing policy and programmatic decision-making [...] the origin of imported infections and characterize transmission chains in settings with very low malaria transmission, and using serology to monitor recent and past exposures in low-transmission settings [...] integrate molecular and genomic data into control program decision-making,...
<em>Plasmodium falciparum</em> merozoite surface protein 1 as asexual blood stage malaria vaccine candidate (Publications)
INTRODUCTION: Malaria represents a tremendous public health challenge in tropical and sub-tropical regions, and currently deployed control strategies are likely insufficient to drive elimination of malaria. Development [...] Development and improvement of malaria vaccines might be key to reduce disease burden. Vaccines targeting asexual blood stages of the parasite have shown limited efficacy when studied in human trials conducted [...] as one of the most promising approaches to provide immune...
Community knowledge, attitude, practices and beliefs associated with persistence of malaria transmission in north-western and southern regions of... (Publications)
cause of malaria, and thought that it is caused by bathing and drinking un-boiled water, or consuming contaminated food that has malaria parasites without warming it. Reported barriers to malaria prevention [...] Kigoma, Mtwara and Ruvuma) with persistently high malaria transmission for more than two decades. RESULTS: Most of the participants had good knowledge of malaria and how it is transmitted but some FGD participants [...] economic activities that potentially contributed to persistence of ...