Emulator-based Bayesian optimization for efficient multi-objective calibration of an individual-based model of malaria (Publications)
framework employing Gaussian process or machine learning emulator functions to calibrate a complex malaria transmission simulator. We demonstrate our approach by optimizing over a high-dimensional parameter [...] a portfolio of multiple fitting objectives built from datasets capturing the natural history of malaria transmission and disease progression. Our approach quickly outperforms previous calibrations, yielding
The 3-phosphoinositide-dependent protein kinase 1 is an essential upstream activator of protein kinase A in malaria parasites (Publications)
t protein kinase A (PKA) signalling is essential for the proliferation of Plasmodium falciparum malaria blood stage parasites. The mechanisms regulating the activity of the catalytic subunit PfPKAc, however [...] function has not been investigated in gametocytes, the sexual blood stage forms that are essential for malaria transmission. By studying a conditional PfPKAc knockdown (cKD) mutant, we confirm the essential role
Transcriptional correlates of malaria in RTS,S/AS01-vaccinated African children: a matched case-control study (Publications)
ted BTM correlations with malaria risk appeared to generalize to healthy, malaria-naive adults. CONCLUSIONS: A prevaccination transcriptomic signature associates with malaria in RTS,S/AS01-vaccinated African [...] we assessed the generalizability of our findings across three controlled human malaria infection studies of healthy, malaria-naive adult RTS,S/AS01 recipients. RESULTS: RTS,S/AS01 vaccination was associated [...] month 3 levels correlated with malaria risk. In contrast, baseline levels...
Modeling support for BMGF Malaria Portfolio Analysis (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/modeling-support-for-bmgf-malaria-portfolio-analysis
in the malaria product portfolio of the Bill & Melinda Gates Foundation and partners. This model-based evidence combined with costs and economic analysis supports strategic decisions for malaria.
Provision of a Scoping Study for a Strategic Environmental Assessment (SEA) on behalf of Target Malaria (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/provision-of-a-scoping-study-for-a-strategic-environmental-assessment-sea-on-behalf-of-target-malaria
Genetically modified mosquitoes represent great potential for malaria control. Any future application of gene drive mosquitoes for malaria control will require many elements, including policy action, [...] to suppress populations of malaria vector mosquitoes. The assessments main objectives are to: (i) raise awareness amongst policy makers of genetic control tools for malaria using gene drives (ii) develop [...] gene drive (the action) and subsequent reduction of malaria (the desired effect)...
Spatio-temporal modelling to assess the impact of climate change on the burden of malaria and to support early warning systems (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/spatio-temporal-modelling-to-assess-the-impact-of-climate-change-on-the-burden-of-malaria-and-to-support-early-warning-systems
climate variability, land use, malaria vector control coverage and socio-economic factors to changes in malaria incidence and mortality; (ii) develop stochastic metapopulation malaria transmission models which [...] statistical models to forecast malaria; (iv) evaluate the effects of environmental vector-control with microbial larvicides on the burden of malaria; and (v) project future malaria burden based on scenarios [...] changes, malaria interventions and socioeconomic effects, which are...
BACKUP Health Cameroon - Improving Access to Malaria Care and Services for Children Under Five: Pilot Project (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/backup-health-cameroon-improving-access-to-malaria-care-and-services-for-children-under-five-pilot-project
approximately $101 million will go to malaria treatment and control programs. These funds are expected to be absorbed through the end of 2023. The National Malaria Control Program (PNLP) is working towards [...] groups of activities: Estimation of the costs of malaria treatment services and care: The aim is to propose three cost models for the management of all malaria care: "basic", "standard" and "comprehensive" [...] goal is to customize openIMIS to meet the needs of malaria care management....
Experience capitalisation of Biovision’s environmental-friendly Malaria and African animal trypanosomiasis control projects from 2005-2020 for greater... (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/experience-capitalisation-of-biovisions-environmental-friendly-malaria-and-african-animal-trypanosomiasis-control-projects-from-2005-2020-for-greater-impact
be an assessment of Biovision’s engagement in Malaria and AAT control. Two major outputs shall be developed based on this review: a) an overview of Malaria and tsetse fly control activities supported through [...] of vector-borne human, animal and plant diseases. The current mandate focuses on programmes for Malaria and AAT control with a flagship character that had been implemented by Biovision and their strong [...] These will address the following four key topics: a) uptake, ownership and...
Malawi Malaria Indicator Survey Quality Assurance Services (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/malawi-malaria-indicator-survey-quality-assurance-services
Malaria indicator surveys are an important source of data on disease burden (parasite prevalence, fever prevalence, etc), and coverage of malaria prevention and case management interventions, particularly [...] decisions. The objective of this mandate of Global Fund was to assess the extent to which the Malawi malaria indicator survey 2021 activities were planned, coordinated, and executed according to the standard
Global Malaria Technical & Training Support Package, Phase 3 (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/global-malaria-technical-training-support-package-phase-3
global malaria control and elimination by shaping global and national malaria control and elimination policies, and ultimately to reduce the malaria burden and to increase the number of malaria-free zones [...] and national malaria strategies. Background Thanks to the scale-up of effective malaria vector control tools such as insecticide-treated mosquito nets, diagnostics and medicines, malaria mortality has [...] Back Malaria action plan, aligned with the 2016-2030 timeline of the Sustainable...