Global diversity and balancing selection of 23 leading <em>Plasmodium falciparum </em>candidate vaccine antigens (Publications)
leading vaccine candidate antigens of P. falciparum using the MalariaGEN Pf3K (version 5.1) resource, comprising more than 2600 genomes from 15 malaria endemic countries. A stringent variant calling pipeline [...] genes encoding 23 leading and novel candidate malaria vaccine antigens including csp, trap, eba175, ama1, rh5, and CelTOS. Our analysis shows that current malaria vaccine formulations are based on rare haplotypes [...] Investigation of the diversity of malaria parasite antigens can...
Analysis and mapping of prospective sources of funding for additional contributions to MEMTI (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/analysis-and-mapping-of-prospective-sources-of-funding-for-additional-contributions-to-memti
The Global Fund to Fight AIDS, Tuberculosis and Malaria set aside funding to incentivize the acceleration of efforts towards elimination of malaria in four countries in the Asia-Pacific region: Papua New [...] New Guinea, Solomon Islands, Vanuatu and Timor-Leste. This "Malaria Elimination in Melanesia and Timor-Leste Initiative" (MEMTI) is additional to Global Fund country funding allocations and is intended [...] development partners. Regarding the identification of all sources of funding for...
Analysis and mapping of prospective sources of funding for additional contributions to MEMTI (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/analysis-and-mapping-of-prospective-sources-of-funding-for-additional-contributions-to-memti
The Global Fund to Fight AIDS, Tuberculosis and Malaria set aside funding to incentivize the acceleration of efforts towards elimination of malaria in four countries in the Asia-Pacific region: Papua New [...] New Guinea, Solomon Islands, Vanuatu and Timor-Leste. This "Malaria Elimination in Melanesia and Timor-Leste Initiative" (MEMTI) is additional to Global Fund country funding allocations and is intended [...] development partners. Regarding the identification of all sources of funding for...
Naturally acquired immunoglobulin (Ig)G subclass antibodies to crude asexual <em>Plasmodium falciparum</em> lysates: evidence for association with... (Publications)
subclass antibody activity present before the beginning of a malaria transmission season (preseason antibody levels) against severe malaria has not been tested in longitudinal studies. We measured IgG [...] significantly different between the children who developed severe malaria and those who remained healthy during an observation period of two malaria transmission seasons. However, elevated levels of IgG1 in relation [...] protection from severe malaria (P = 0.02). Conversely, elevated levels...
The risk of malarial infections and disease in Papua New Guinean children (Publications)
vivax = 5.28), they were 21 times more likely to develop symptomatic P. falciparum malaria (1.17/year) than P. vivax malaria (0.06/year). Children greater than nine years of age had a reduced risk of acquiring [...] to symptomatic P. falciparum malaria remained incomplete. These observations suggest that different mechanisms of immunity may be important for protection from these malaria species [...] study of 206 Papua New Guinean school children, we examined risk of reinfection and symptomatic ...
Naturally acquired immunoglobulin (Ig)G subclass antibodies to crude asexual <em>Plasmodium falciparum</em> lysates: evidence for association with... (Publications)
subclass antibody activity present before the beginning of a malaria transmission season (preseason antibody levels) against severe malaria has not been tested in longitudinal studies. We measured IgG [...] significantly different between the children who developed severe malaria and those who remained healthy during an observation period of two malaria transmission seasons. However, elevated levels of IgG1 in relation [...] protection from severe malaria (P = 0.02). Conversely, elevated levels...
The risk of malarial infections and disease in Papua New Guinean children (Publications)
vivax = 5.28), they were 21 times more likely to develop symptomatic P. falciparum malaria (1.17/year) than P. vivax malaria (0.06/year). Children greater than nine years of age had a reduced risk of acquiring [...] to symptomatic P. falciparum malaria remained incomplete. These observations suggest that different mechanisms of immunity may be important for protection from these malaria species [...] study of 206 Papua New Guinean school children, we examined risk of reinfection and symptomatic ...
Increased levels of anti-PfCSP antibodies in post-pubertal females versus males immunized with PfSPZ Vaccine does not translate into increased... (Publications)
shown differences in the risk of malaria infection and sickness between males and females, little is known about sex differences in vaccine-induced immunity to malaria. Identifying such differences could [...] could elucidate important aspects of malaria biology and facilitate development of improved approaches to malaria vaccination. METHODS: Using a standardized enzyme-linked immunosorbent assay, IgG antibodies [...] were associated with differential protection against naturally transmitted Pf...
Increased levels of anti-PfCSP antibodies in post-pubertal females versus males immunized with PfSPZ Vaccine does not translate into increased... (Publications)
shown differences in the risk of malaria infection and sickness between males and females, little is known about sex differences in vaccine-induced immunity to malaria. Identifying such differences could [...] could elucidate important aspects of malaria biology and facilitate development of improved approaches to malaria vaccination. METHODS: Using a standardized enzyme-linked immunosorbent assay, IgG antibodies [...] were associated with differential protection against naturally transmitted Pf...
Vaccine potentials of an intrinsically unstructured fragment derived from the blood stage-associated <em>Plasmodium falciparum</em> protein PFF0165c (Publications)
with its low polymorphism and association with clinical protection from malaria in humans, warrant its further development as a malaria vaccine candidate [...] We have identified new malaria vaccine candidates through the combination of bioinformatics prediction of stable protein domains in the Plasmodium falciparum genome, chemical synthesis of polypeptides [...] assays, and association of an antigen-specific antibody response with protection against clinical malaria. Within the predicted open...
