Trisubstituted pyrimidines as efficacious and fast-acting antimalarials (Publications)
mouse model of malaria. The most promising compound (13) showed a reduction in parasitemia of 96% when dosed at 30 mg/kg orally once a day for 4 days in the P. berghei mouse model of malaria. It also demonstrated
Clara Champagne (People)
https://www.swisstph.ch/en/staff/profile/people/clara-champagne
Intervention Modelling group to provide country specific modelling support for decision making on malaria interventions. Her recent work includes P. vivax modelling with applications in Central America and [...] health workers geographical placement. She has also participated in the modelling work supporting malaria control programmes within the HBHI initiative. Complete publication list available on Google Scholar
Dengue fever in Dar es Salaam, Tanzania: clinical features and outcome in populations of black and non-black racial category (Publications)
are under-reported in Africa and often mistaken for malaria. These results highlight the need to introduce point-of-care tests, beside the one for malaria, to detect outbreaks and orientate diagnosis. TRIAL [...] clinical presentation, including warning signs, was assessed by logistic regression adjusted for age, malaria coinfection, secondary dengue and duration of symptoms at inclusion. The independent association [...] attended care after a slightly longer duration of symptoms (median of 2.9...
Long-lasting insecticidal net (LLIN) ownership, use and cost of implementation after a mass distribution campaign in Kasai Occidental Province,... (Publications)
BACKGROUND: Long-lasting insecticidal nets (LLIN) are a highly effective means for preventing malaria infection and reducing associated morbidity and mortality. Mass free distribution campaigns have been [...] six months after the mass distribution. Descriptive statistics were used to measure changes in key malaria household indicators. LLIN ownership and use were compared between delivery strategies. Univariate [...] have a significant impact on LLIN use (69.6% [95% CI 63.1-75.5%] versus 65.7%...
Long-lasting insecticidal net (LLIN) ownership, use and cost of implementation after a mass distribution campaign in Kasai Occidental Province,... (Publications)
BACKGROUND: Long-lasting insecticidal nets (LLIN) are a highly effective means for preventing malaria infection and reducing associated morbidity and mortality. Mass free distribution campaigns have been [...] six months after the mass distribution. Descriptive statistics were used to measure changes in key malaria household indicators. LLIN ownership and use were compared between delivery strategies. Univariate [...] have a significant impact on LLIN use (69.6% [95% CI 63.1-75.5%] versus 65.7%...
Dengue fever in Dar es Salaam, Tanzania: clinical features and outcome in populations of black and non-black racial category (Publications)
are under-reported in Africa and often mistaken for malaria. These results highlight the need to introduce point-of-care tests, beside the one for malaria, to detect outbreaks and orientate diagnosis. TRIAL [...] clinical presentation, including warning signs, was assessed by logistic regression adjusted for age, malaria coinfection, secondary dengue and duration of symptoms at inclusion. The independent association [...] attended care after a slightly longer duration of symptoms (median of 2.9...
Plasmodium vivax Transmission Model (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/plasmodium-vivax-transmission-model
parasite is dominant. This compartmental model accounts specifically for the liver stages of P. vivax malaria and it has recently been refined to include imported infections as well as treatment of blood and/or [...] data on reported local and imported cases, and it can be used to simulate the expected impact of malaria treatment schemes, vector control strategies, reactive interventions or mass drug administration
Imaging of <em>Plasmodium</em> liver stages to drive next-generation antimalarial drug discovery (Publications)
Most malaria drug development focuses on parasite stages detected in red blood cells, even though to achieve eradication, next-generation drugs active against both erythrocytic and exo-erythrocytic forms [...] imidazolopiperazine confers complete causal prophylactic protection (15 mg/kg) in rodent models of malaria and shows potent in vivo blood-stage therapeutic activity. The open source chemical tools resulting
Micro-epidemiological structuring of <em>Plasmodium falciparum</em> parasite populations in regions with varying transmission intensities in Africa (Publications)
Background: The first models of malaria transmission assumed a completely mixed and homogeneous population of parasites. Recent models include spatial heterogeneity and variably mixed populations. However [...] pairs is predicted by relatedness in space and time. Conclusions: Our findings suggest that targeted malaria control will benefit the surrounding community, but unfortunately also that emerging drug resistance
Discovery and characterization of ACT-451840: an antimalarial drug with a novel mechanism of action (Publications)
More than 40 % of the world's population is at risk of being infected with malaria. Most malaria cases occur in the countries of sub-Saharan Africa, Central and South America, and Asia. Resistance to standard