Discovery and characterization of potent, efficacious, orally available antimalarial plasmepsin X inhibitors and preclinical safety assessment of... (Publications)
Plasmepsin X (PMX) is an essential aspartyl protease controlling malaria parasite egress and invasion of erythrocytes, development of functional liver merozoites (prophylactic activity), and blocking [...] days. This work demonstrates the potential to deliver PMX inhibitors with in vivo efficacy to treat malaria.
VectorDisk: a microfluidic platform integrating diagnostic markers for evidence-based mosquito control (Publications)
identify mosquito and malaria parasite species as well as insecticide resistance mechanisms. In the second study, purified nucleic acids served as samples to test arboviral and malaria infective mosquito
Novel antimalarial tetrazoles and amides active against the hemoglobin degradation pathway in <em>Plasmodium falciparum</em> (Publications)
Malaria control programs continue to be threatened by drug resistance. To identify new antimalarials, we conducted a phenotypic screen and identified a novel tetrazole-based series that shows fast-kill [...] polymerization pathway and that can form the basis of future optimization efforts to develop a new malaria treatment.
Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy (Publications)
the malaria parasite Plasmodium falciparum, namely tyrosine RS (PfYRS). ML901 exerts whole-life-cycle-killing activity with low nanomolar potency and single-dose efficacy in a mouse model of malaria. X-ray
Massive Open Online Course on Insecticide Resistance Management (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/massive-open-online-course-on-insecticide-resistance-management
the authoritative resource for Insecticide Resistance Management (IRM) in the mosquito vectors of malaria. However, IRM is an applied science, and there is a need to translate theory into practice. Whilst [...] to anyone, but will be specifically designed for, and promoted to, those involved with practical malaria vector control.
Luis Segura (People)
https://www.swisstph.ch/en/staff/profile/people/luis-segura
by The Global Fund in the Americas, Africa, and South East Asia regions. He also has led a large malaria program in Equatorial Guinea, which in addition to communicational interventions, vector control [...] technical and logistic support to case management, included clinical trials of a sporozoite based malaria vaccine. His experience includes also operational research and monitoring of maternal-child and
Novel antimalarial tetrazoles and amides active against the hemoglobin degradation pathway in <em>Plasmodium falciparum</em> (Publications)
Malaria control programs continue to be threatened by drug resistance. To identify new antimalarials, we conducted a phenotypic screen and identified a novel tetrazole-based series that shows fast-kill [...] polymerization pathway and that can form the basis of future optimization efforts to develop a new malaria treatment.
VectorDisk: a microfluidic platform integrating diagnostic markers for evidence-based mosquito control (Publications)
identify mosquito and malaria parasite species as well as insecticide resistance mechanisms. In the second study, purified nucleic acids served as samples to test arboviral and malaria infective mosquito
Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy (Publications)
the malaria parasite Plasmodium falciparum, namely tyrosine RS (PfYRS). ML901 exerts whole-life-cycle-killing activity with low nanomolar potency and single-dose efficacy in a mouse model of malaria. X-ray
Discovery and characterization of potent, efficacious, orally available antimalarial plasmepsin X inhibitors and preclinical safety assessment of... (Publications)
Plasmepsin X (PMX) is an essential aspartyl protease controlling malaria parasite egress and invasion of erythrocytes, development of functional liver merozoites (prophylactic activity), and blocking [...] days. This work demonstrates the potential to deliver PMX inhibitors with in vivo efficacy to treat malaria.
