Luis Segura (People)
https://www.swisstph.ch/en/staff/profile/people/luis-segura
by The Global Fund in the Americas, Africa, and South East Asia regions. He also has led a large malaria program in Equatorial Guinea, which in addition to communicational interventions, vector control [...] technical and logistic support to case management, included clinical trials of a sporozoite based malaria vaccine. His experience includes also operational research and monitoring of maternal-child and
Discovery and characterization of potent, efficacious, orally available antimalarial plasmepsin X inhibitors and preclinical safety assessment of... (Publications)
Plasmepsin X (PMX) is an essential aspartyl protease controlling malaria parasite egress and invasion of erythrocytes, development of functional liver merozoites (prophylactic activity), and blocking [...] days. This work demonstrates the potential to deliver PMX inhibitors with in vivo efficacy to treat malaria.
Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy (Publications)
the malaria parasite Plasmodium falciparum, namely tyrosine RS (PfYRS). ML901 exerts whole-life-cycle-killing activity with low nanomolar potency and single-dose efficacy in a mouse model of malaria. X-ray
VectorDisk: a microfluidic platform integrating diagnostic markers for evidence-based mosquito control (Publications)
identify mosquito and malaria parasite species as well as insecticide resistance mechanisms. In the second study, purified nucleic acids served as samples to test arboviral and malaria infective mosquito
Massive Open Online Course on Insecticide Resistance Management (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/massive-open-online-course-on-insecticide-resistance-management
the authoritative resource for Insecticide Resistance Management (IRM) in the mosquito vectors of malaria. However, IRM is an applied science, and there is a need to translate theory into practice. Whilst [...] to anyone, but will be specifically designed for, and promoted to, those involved with practical malaria vector control.
The development of an ivermectin-based attractive toxic sugar bait (ATSB) to target <em>Anopheles arabiensis</em> (Publications)
Africa are moving towards malaria-elimination, mostly thanks to successful vector control campaigns. However, elimination has proven challenging, resulting in the persistence of malaria transmission. It is now [...] now accepted that in order to eliminate malaria, new complementary vector control approaches must be developed. This study describes the development of a sugar-baited resting place containing a toxic dose
Surveillance of molecular markers of <em>Plasmodium falciparum</em> artemisinin resistance (<em>kelch</em>13 mutations) in Papua New Guinea between... (Publications)
Plasmodium falciparum resistance to artemisinin-based combination therapy (ACT) is a global threat to malaria control and elimination efforts. Mutations in the P. falciparum kelch13 gene (Pfk13) that are associated [...] in other parts of PNG is unknown. We investigated the prevalence of Pfk13 mutations in multiple malaria-endemic regions of PNG. P. falciparum isolates (n = 1152) collected between 2016 and 2018 and assessed [...] Continued surveillance for molecular markers of drug resistance is...
Infection and co-infection with helminths and <em>Plasmodium</em> among school children in Côte d'Ivoire: results from a national cross-sectional... (Publications)
Helminth infection and malaria remain major causes of ill-health in the tropics and subtropics. There are several shared risk factors (e.g., poverty), and hence, helminth infection and malaria overlap geographically [...] provide a rationale to combine control interventions that simultaneously aim at helminthiases and malaria
Effects of changing mosquito host searching behaviour on the cost effectiveness of a mass distribution of long-lasting, insecticidal nets: a modelling... (Publications)
BACKGROUND: The effectiveness of long-lasting, insecticidal nets (LLINs) in preventing malaria is threatened by the changing biting behaviour of mosquitoes, from nocturnal and endophagic to crepuscular [...] stochastic simulation models, we studied the impact of a mass LLIN distribution on Plasmodium falciparum malaria. Specifically, we looked at impact in terms of episodes prevented during the effective life of the [...] occur within the same mosquito population. LLINs are likely cost effective...
Effects of changing mosquito host searching behaviour on the cost effectiveness of a mass distribution of long-lasting, insecticidal nets: a modelling... (Publications)
BACKGROUND: The effectiveness of long-lasting, insecticidal nets (LLINs) in preventing malaria is threatened by the changing biting behaviour of mosquitoes, from nocturnal and endophagic to crepuscular [...] stochastic simulation models, we studied the impact of a mass LLIN distribution on Plasmodium falciparum malaria. Specifically, we looked at impact in terms of episodes prevented during the effective life of the [...] occur within the same mosquito population. LLINs are likely cost effective...
