Access to artemisinin-based anti-malarial treatment and its related factors in rural Tanzania (Publications)
BACKGROUND: Artemisinin-based combination treatment (ACT) has been widely adopted as one of the main malaria control strategies. However, its promise to save thousands of lives in sub-Saharan Africa depends [...] of fever onset. In neither of the HDSS site was age, sex, socio-economic status or seasonality of malaria found to be significantly correlated with timely access. CONCLUSION: Timely access to authorized [...] major bottle neck and new more innovative interventions are needed to raise...
Asymptomatic <em>Plasmodium</em> infection and glycemic control in adults: results from a population-based survey in south-central Côte d'Ivoire (Publications)
associations of Plasmodium infection (PI) with fasting glucose (FG) and glycated hemoglobin (HbA1c) in malaria-endemic south-central Cote d'Ivoire. METHODS: We studied 979 participants (non-pregnant; no treated [...] Fasting venous blood was obtained for PI, FG, and HbA1c assessment. We defined PI as a positive malaria rapid diagnostic test (RDT) or microscopic identification of Plasmodium species. We applied multivariable [...] diagnosis in the presence of asymptomatic PI may misclassify or...
Mosquito net use in early childhood and survival to adulthood in Tanzania (Publications)
BACKGROUND It has been hypothesized that in high-transmission settings, malaria control in early childhood (
Mosquito net use in early childhood and survival to adulthood in Tanzania (Publications)
BACKGROUND It has been hypothesized that in high-transmission settings, malaria control in early childhood (
Systematic review of indoor residual spray efficacy and effectiveness against <em>Plasmodium falciparum</em> in Africa (Publications)
Indoor residual spraying (IRS) is an important part of malaria control. There is a growing list of insecticide classes; pyrethroids remain the principal insecticide used in bednets but recently, novel [...] of different IRS insecticides. We report that long-lasting IRS formulations substantially reduce malaria, though their benefit over cheaper, shorter-lived formulations depends on local factors including
Multiplex assay for species identification and monitoring of insecticide resistance in <em>Anopheles punctulatus</em> group populations of Papua New... (Publications)
complex [eight cryptic species]) are principal vectors of malaria and filariasis in the Southwest Pacific. Given significant effort to reduce malaria and filariasis transmission through insecticide-treated
Etiology of anemia among infants, school-aged children, and young non-pregnant women in different settings of south-central Côte d'Ivoire (Publications)
samples were subjected to standardized quality-controlled methods. We found high prevalence of anemia, malaria, inflammation, and deficiencies of iron, riboflavin, and vitamin A but low prevalence and intensities [...] factor for anemia in non-pregnant women. Our findings call for interventions to protect infants from malaria, improved intake of dietary iron, and given the importance of anemia of inflammation in school-aged
Ancient Chinese methods are remarkably effective for the preparation of artemisinin-rich extracts of Qing Hao with potent antimalarial activity (Publications)
artemisinin is an important antimalarial drug and the herb itself is being grown and used locally for malaria treatment although this practice is controversial. Here we show that the ancient Chinese methods [...] in P. berghei infected mice. The implications of these results are discussed in the context of malaria treatment using A. annua infusions
Discovery and characterization of potent, efficacious, orally available antimalarial plasmepsin X inhibitors and preclinical safety assessment of... (Publications)
Plasmepsin X (PMX) is an essential aspartyl protease controlling malaria parasite egress and invasion of erythrocytes, development of functional liver merozoites (prophylactic activity), and blocking [...] days. This work demonstrates the potential to deliver PMX inhibitors with in vivo efficacy to treat malaria.
VectorDisk: a microfluidic platform integrating diagnostic markers for evidence-based mosquito control (Publications)
identify mosquito and malaria parasite species as well as insecticide resistance mechanisms. In the second study, purified nucleic acids served as samples to test arboviral and malaria infective mosquito
