The effect of <em>Plasmodium falciparum</em> exposure and maternal anti-circumsporozoite protein antibodies on responses to RTS,S/AS01E vaccination in... (Publications)
BACKGROUND: The RTS,S/AS01(E) malaria vaccine showed lower antibody response and protective efficacy in infants aged 6-12 weeks compared with children aged 5-17 months (for whom this vaccine is recommended) [...] antibody immunoglobulin G (IgG) responses measured by ELISA and pre-vaccination serological markers of malaria exposure by assessing the IgG levels against 1000 P falciparum antigens using partial proteome m [...] The negative effect of maternal anti-CSP IgG in infants did not appear to...
First-trimester artemisinin derivatives and quinine treatments and the risk of adverse pregnancy outcomes in Africa and Asia: a meta-analysis of... (Publications)
artemisinin combination therapy regimens to treat malaria in early pregnancy are likely to outweigh the adverse outcomes of partially treated malaria, which can occur with oral quinine because of the known [...] safety data in human pregnancies, have prevented artemisinin derivatives from being recommended for malaria treatment in the first trimester except in lifesaving circumstances. We conducted a meta-analysis [...] antimalarial treatment. METHODS AND FINDINGS: Electronic databases including...
Targeting <em>Plasmodium </em>plasmepsin V: hitting two birds with one stone (Publications)
al. reveals an important role for plasmepsin V (PMV), an aspartyl protease, in the development of malaria transmission stages. The authors showed that PMV activity is critical for protein export in these
Targeting <em>Plasmodium </em>plasmepsin V: hitting two birds with one stone (Publications)
al. reveals an important role for plasmepsin V (PMV), an aspartyl protease, in the development of malaria transmission stages. The authors showed that PMV activity is critical for protein export in these
Inference for entomological semi-field experiments: fitting a mathematical model assessing personal and community protection of vector-control... (Publications)
and metofluthrin spatial repellents, as well as combined interventions for Plasmodium falciparum malaria in Anopleles minimus. Overall, all interventions had both personal and community effects, preventing [...] than just reduction in biting, to be parameterised and highlights the tools assessed as promising malaria interventions.
Acceptability and use of insecticide impregnated bednets in northern Ghana (Publications)
washing soaps could improve protection for young children. The success of the promotion of IIBNs in malaria control programmes will depend on the cost of the package and the time of year that it is delivered [...] the intervention in this study, and it should be included as an important component of national malaria control programmes.
drLumi: an open-source package to manage data, calibrate, and conduct quality control of multiplex bead-based immunoassays data analysis (Publications)
bead-based immunoassay in a study aiming to measure correlates of risk or protection from malaria of the RTS,S malaria vaccine nested in the Phase 3 randomized controlled trial of this vaccine.
Two successful decades of Swiss collaborations to develop new anti-malarials (Publications)
Over the last two decades there has been a renaissance in the pipeline of new drugs targeting malaria, with the launch of new products that help save the lives of children throughout the world. In addition [...] Third, the emergence of product-development-partnerships, in this case led by the Medicines for Malaria Venture, based in Geneva, has helped to catalyze the development of new medicines and bring the community
Longitudinal tracking and quantification of individual <em>Plasmodium falciparum </em>clones in complex infections (Publications)
falciparum strains in multi-clonal infections is essential for investigating infection dynamics of malaria. The traditional genotyping techniques did not permit tracking changes in individual clone density [...] longitudinally by Amp-Seq despite MOI > 1, thus providing an additional parameter for investigating malaria infection dynamics. Amp-Seq based genotyping of longitudinal samples improves detection of minority
<em>Anopheles arabiensis</em> and <em>A. gambiae</em> chromosomal inversion polymorphism, feeding and resting behaviour in relation to insecticide... (Publications)
evaluated in relation to chromosomal inversion polymorphism, feeding and resting behaviour of these malaria vectors in Tanzania. Blood-fed mosquitoes from pit traps outdoors, exit traps on windows and ind [...] of DDT was perceived as a disadvantage, whereas lambda-cyhalothrin apparently had more impact on malaria transmission by An.arabiensis.
