Dynamics of anemia in relation to parasitic infections, micronutrient status, and growing age in south-central Côte d'Ivoire (Publications)
Background. Parasitic diseases (e.g., malaria and helminthiases) exert enormous burdens on public health and social wellbeing. Moreover, parasitic infections are important causes of anemia in tropical [...] include the distribution of long-lasting insecticidal nets, intermittent preventive treatment for malaria, regular anthelmintic drug administration, and improved intake of bioavailable iron, coupled with
Current progress in the development and use of artemether for chemoprophylaxis of major human schistosome parasites (Publications)
schistosomiasis, a chronic and debilitating parasitic disease of the tropics, is ranked second after malaria in terms of public health importance. At present, there is no vaccine available, and chemotherapy [...] with artemether, the methyl ether of dihydroartemisinin, already widely used for the treatment of malaria. The present article reviews the literature that led to the development of artemether for chemop
The potential of artemether for the control of schistosomiasis (Publications)
Schistosomiasis continues to rank - following malaria - at the second position of the world's parasitic diseases in terms of the extent of endemic areas and the number of infected people. There is yet [...] Interestingly, derivatives of artemisinin, which are already effectively used in the treatment of malaria, also exhibit antischistosomal properties. Significant advances have been made with artemether, the
Prospective risk of morbidity in relation to multiplicity of infection with <em>Plasmodium falciparum </em>in Sao Tomé (Publications)
confounding by patterns of health service usage is an alternative explanation. The incidence of clinical malaria episodes was only a little higher in children than in adults. This weak age-dependence in clinical [...] a consequence of a cohort effect resulting from resurgence of the disease after the breakdown of malaria control programs in the 1980s.
Urban agricultural land use and characterization of mosquito larval habitats in a medium-sized town of Côte d'Ivoire (Publications)
urban dwellers. Some crop systems create suitable mosquito breeding sites and thus might affect malaria transmission. The purpose of this study was to identify, map, and characterize potential mosquito [...] and rice paddies. Our findings have important bearings for the epidemiology and control of urban malaria in sub-Saharan Africa
New <em>in vitro</em> interaction-parasite reduction ratio assay for early derisk in clinical development of antimalarial combinations (Publications)
The development and spread of drug-resistant phenotypes substantially threaten malaria control efforts. Combination therapies have the potential to minimize the risk of resistance development but require [...] will significantly improve and streamline the economic development of new drug combinations for malaria and potentially also in other therapeutic areas.
Life expectancy of <em>Anopheles funestus</em> is double that of <em>Anopheles arabiensis</em> in southeast Tanzania based on mark-release-recapture... (Publications)
stricto mosquitoes are major East African malaria vectors. Understanding their dispersal and population structure is critical for developing effective malaria control tools. Three mark-release-recapture
Inference for entomological semi-field experiments: fitting a mathematical model assessing personal and community protection of vector-control... (Publications)
and metofluthrin spatial repellents, as well as combined interventions for Plasmodium falciparum malaria in Anopleles minimus. Overall, all interventions had both personal and community effects, preventing [...] than just reduction in biting, to be parameterised and highlights the tools assessed as promising malaria interventions.
Antiprotozoal <em>Nor</em>-triterpene alkaloids from <em>Buxus sempervirens</em> L (Publications)
Malaria and human African trypanosomiasis (HAT; sleeping sickness) are life-threatening tropical diseases caused by protozoan parasites. Due to limited therapeutic options, there is a compelling need for [...] was identified as possessing strong and selective in vitro activity against the causative agent of malaria tropica, Plasmodium falciparum (Pf). The purpose of this study is the isolation of additional alkaloids
A comparative study of the efficacies of chloroquine and a pyrimethamine-dapsone combination in clearing <em>Plasmodium falciparum</em> parasitaemia... (Publications)
100 mg dapsone for children 10 or more years old) as a single dose. Children were followed-up for malaria parasitaemia at days 2, 7 and 14 after screening, randomization and treatment. The slide positivity [...] pyrimethamine-dapsone appears to be a better choice than chloroquine as a chemoprophylactic regimen for malaria in this area. Although they need to be confirmed in a larger study, these results may be of interest