A worldwide map of <em>Plasmodium falciparum</em> K13-propeller polymorphisms (Publications)
BACKGROUND: Recent gains in reducing the global burden of malaria are threatened by the emergence of Plasmodium falciparum resistance to artemisinins. The discovery that mutations in portions of a P. [...] analyzed the K13-propeller sequence polymorphism in 14,037 samples collected in 59 countries in which malaria is endemic. Most of the samples (84.5%) were obtained from patients who were treated at sentinel
Antiprotozoal activities of tetrazole-quinolines with aminopiperidine linker (Publications)
sickness) and Malaria both are insect vectored tropical diseases. Only a couple of drugs is able to cure HAT, but all of them are toxic, prone to resistance and require parenteral administration. Malaria is responsible
PHARE: a bioinformatics pipeline for compositional profiling of multiclonal <em>Plasmodium falciparum</em> infections from long-read Nanopore... (Publications)
detect and track the spread of these clones is crucial for effective malaria control and treatment. However, in endemic settings, malaria infected people often carry multiple P. falciparum clones simultaneously
Repositioning and characterization of 1-(pyridin-4-yl)pyrrolidin-2-one derivatives as <em>Plasmodium </em>cytoplasmic prolyl-trna synthetase... (Publications)
parasites at a selection pressure of 3 x IC50) constitute unfavorable features for treatment of malaria. However, potent blood stage and antischizontal activity are compelling for causal prophylaxis which [...] Encouraging preliminary off-target profile and oral efficacy in a humanized murine model of Pf malaria allowed us to conclude that 1-(pyridin-4-yl)pyrrolidin-2-one derivatives represent a promising starting
Laboratory-based efficacy evaluation of <em>Bacillus thuringiensis</em> var. <em>israelensis </em>and temephos larvicides against larvae of... (Publications)
BACKGROUND: Malaria, transmitted by the bite of infective female Anopheles mosquitoes, remains a global public health problem. The presence of an invasive Anopheles stephensi, capable of transmitting [...] The ecology of An. stephensi is different from that of Anopheles arabiensis, the primary Ethiopian malaria vector, and this suggests that alternative control strategies may be necessary. Larviciding may be
The <em>Plasmodium </em>lactate/H+ transporter PfFNT is essential and druggable <em>in vivo</em> (Publications)
Malaria parasites in the blood stage express a single transmembrane transport protein for the release of the glycolytic end product l-lactate/H(+) from the cell. This transporter is a member of the strictly [...] ty of the PfFNT target on a genetic level, and established its in vivo druggability using mouse malaria models. We found that, besides a previously identified PfFNT G107S resistance mutation, selection
Prevalence and determinants of undernutrition in schoolchildren in the Kilombero district, South-Eastern Tanzania (Publications)
wasting, and underweight, while logistic regression analyses examined sociodemographic background, malaria infection, anaemia, anthropometric measures, and dietary diversity score as potential factors. The [...] obesity was 11.8%, 4.3%, 3.9%, 11.1%, and 2.0%, respectively. Overall, 1.5% of the children had malaria, as determined by rapid diagnostic tests, and 0.4% had severe anaemia. Univariate analysis indicated
Care seeking and treatment of febrile children with and without danger signs of severe disease in northern Uganda: results from three household... (Publications)
(danger signs) in rural communities are crucial for preventing complications and death from severe malaria, pneumonia, and diarrhea. We set out to determine the treatment-seeking practices and treatment patterns [...] of age with an acute febrile illness, with or without danger signs of severe disease, in a highly malaria-endemic area of northern Uganda. Three household surveys were conducted from November through December
Identification of the asymptomatic <em>Plasmodium falciparum</em> and <em>Plasmodium vivax</em> gametocyte reservoir under different transmission... (Publications)
gametocyte carriage and density is essential to design interventions that most effectively reduce malaria human-to-mosquito transmission. METHODOLOGY/PRINCIPAL FINDINGS: Plasmodium falciparum and P. vivax [...] 178/348, P. vivax 235/398). CONCLUSIONS/SIGNIFICANCE: Interventions to reduce human-to-mosquito malaria transmission in moderate-high endemicity settings will have the greatest impact when children are
Synthesis of antimalarial 1,2,4-trioxanes via photooxygenation of a chiral allylic alcohol (Publications)
series of monocyclic and spirobicyclic 1,2,4-trioxanes (5, 6). Two products show significant anti-Malaria activity against Plasmodium falciparum when compared with chloroquine