Ancistrotanzanine C and related 5,1'- and 7,3'-coupled naphthylisoquinoline alkaloids from <em>Ancistrocladus tanzaniensis</em> (Publications)
and chiroptical methods. The biological activities of the alkaloids against the pathogens causing malaria tropica, leishmaniasis, Chagas' disease, and African sleeping sickness were evaluated
Synthesis and antiprotozoal activity of azabicyclo-nonane pyrimidine hybrids (Publications)
protozoan parasites. A series of fused hybrids were synthesized and tested in vitro against pathogens of malaria tropica and sleeping sickness. The activities and selectivities of compounds strongly depended on
The pharmacokinetics and drug-drug interactions of ivermectin in <em>Aedes aegypti</em> mosquitoes (Publications)
Mosquitoes are vectors of major diseases such as dengue fever and malaria. Mass drug administration of endectocides to humans and livestock is a promising complementary approach to current insecticide-based
Quinuclidine derivatives as potential antiparasitics (Publications)
causative organism of human African trypanosomiasis) and Plasmodium falciparum (a causative agent of malaria), but through an unknown mode(s) of action
Epimers of bicyclo[2.2.2]octan-2-ol derivatives with antiprotozoal activity (Publications)
s and several of their esters have shown promising activity against the causative organisms for malaria and sleeping sickness. The base-catalyzed epimerization of the alcohols was carried out by different
Spatial epidemiology in zoonotic parasitic diseases: insights gained at the 1st International Symposium on Geospatial Health in Lijiang, China, 2007 (Publications)
and water-borne helminth infections, as well as arthropod-borne diseases such as leishmaniasis, malaria and lymphatic filariasis. The work made public at this occasion is briefly summarized here to highlight
Tests diagnostiques rapides (TDR): la panacée pour le praticien? (Publications)
implementing a sequential diagnostic strategy to avoid extensive investigations. Using the example of malaria, a new strategy that includes a RDT as first-line emergency diagnostic tool and, when negative, delayed
Immunoglobulin kappa light-chain V, J, and C gene sequences of the owl monkey <em>Aotus nancymaae</em> (Publications)
supports the proposal to use the Aotus Plasmodium falciparum infection model for the evaluation of malaria vaccine candidates
QSAR guided synthesis of simplified antiplasmodial analogs of naphthylisoquinoline alkaloids (Publications)
pharmacologic properties make them suitable lead structures for new agents, in particular against malaria. Since these natural products are not easy to isolate in sufficient quantities or to synthesize
Vector-borne diseases in humans and animals: activities of the Swiss Tropical Institut and risks for Switzerland (Publications)
This overview presents the Swiss Tropical Institute's (STI) activities on vector-borne diseases (malaria, trypanosomosis, and leishmaniosis in humans and tick-borne diseases in livestock), describes the