Monitoring of selected health indicators in children living in a copper mine development area in northwestern Zambia (Publications)
The epidemiology of malaria, anaemia and malnutrition in children is potentially altered in mining development areas. In a copper extraction project in northwestern Zambia, a health impact assessment (HIA)
Fiona Vanobberghen (People)
https://www.swisstph.ch/en/staff/profile/people/fiona-vanobberghen
on Design and analysis of pharmacokinetic and pharmacodynamic (PK/PD) studies for helminths and malaria In addition, my experience and interests span HIV epidemiology and clinical trials, the use of marginal
Bioisosteric ferrocenyl aminoquinoline-benzimidazole hybrids: antimicrobial evaluation and mechanistic insights (Publications)
activity against the chloroquine-sensitive NF54 and multi-drug resistant K1 strains of the human malaria parasite, Plasmodium falciparum. All compounds were active against the two strains, generally showing
Immune system development varies according to age, location, and anemia in African children (Publications)
Mozambique by detailed immunophenotyping of longitudinal blood samples collected during the RTS,S malaria vaccine phase 3 trial. In these cohorts, the composition of the immune system is dynamically transformed
Sustaining LLIN coverage with continuous distribution: the school net programme in Tanzania (Publications)
Most malaria-endemic countries have struggled in the past decade to establish effective national-scale continuous distribution mechanisms for long-lasting insecticidal nets (LLINs). Since the implementation
Candidate-gene based GWAS identifies reproducible DNA markers for metabolic pyrethroid resistance from standing genetic variation in East African... (Publications)
resistance to pyrethroid insecticides is widespread in Anopheles mosquitoes and is a major threat to malaria control. DNA markers would aid predictive monitoring of resistance, but few mutations have been
Mbandakamine-type naphthylisoquinoline dimers and related alkaloids from the central African liana <em>ancistrocladus ealaensis </em>with... (Publications)
ealaines A-D (11-14). The new mbandakamines C (4) and D (5) showed pronounced activities against the malaria parasite Plasmodium falciparum, and they were likewise found to display strong cytotoxic activities
Genetic validation of <em>Pf</em>FKBP35 as an antimalarial drug target (Publications)
Plasmodium falciparum accounts for the majority of over 600,000 malaria-associated deaths annually. Parasites resistant to nearly all antimalarials have emerged and the need for drugs with alternative
Global metabolic responses of NMRI mice to an experimental <em>Plasmodium berghei</em> infection (Publications)
metabolic profiling may provide a sensitive diagnostic tool of Plasmodium infection and the control of malaria more generally
Histopathological changes in adult <em>Schistosoma japonicum</em> harbored in mice treated with a single dose of mefloquine (Publications)
New research has shown that mefloquine, an arylaminoalcohol used against malaria, is active against Schistosoma japonicum and Schistosoma mansoni in vivo. To enhance our understanding of the potential
