False-negative malaria rapid diagnostic tests in Rwanda: impact of <em>Plasmodium falciparum</em> isolates lacking <em>hrp2</em> and declining malaria... (Publications)
and the Plasmodium lactate dehydrogenase (pLDH) to microscopy (thick smears) for the diagnosis of malaria. PCR was used to determine whether deletions of the histidine-rich central repeat region of the hrp2 [...] CONCLUSION: This prospective study of RDT performance coincided with a decline in the intensity of malaria transmission in Kibirizi (fall in slide positivity from 46 to 3%). This decline was associated with [...] could reduce the impact of false-negative HRP2-based RDTs for detection of...
Rapid diagnostic test-based management of malaria: an effectiveness study in Papua New Guinean infants with <em>Plasmodium falciparum</em> and... (Publications)
Background. In malaria-endemic areas it is recommended that febrile children be tested for malaria by rapid diagnostic test (RDT) or blood slide (BS) and receive effective malaria treatment only if results [...] P. vivax malaria on the basis of RDT but BSs were negative; 16 had LRTIs; 3 had alternative diagnoses. Of these 24, 22 were cured at day 28. Two children died of illnesses other than malaria and were RDT [...] RDT and BS negative at the initial and subsequent visits.Conclusion. Treatment...
"My children and I will no longer suffer from malaria": a qualitative study of the acceptance and rejection of indoor residual spraying to prevent... (Publications)
BACKGROUND: The objective of this study was to identify attitudes and misconceptions related to acceptance or refusal of indoor residual spraying (IRS) in Tanzania for both the general population and
Reductions in malaria and anaemia case and death burden at hospitals following scale-up of malaria control in Zanzibar, 1999-2008 (Publications)
CONCLUSIONS: Scaling-up effective malaria interventions reduced malaria-related burden at health facilities by over 75% within 5 years. In high-malaria settings, intensified malaria control can substantially [...] groups combined, malaria deaths had fallen by an estimated 90% (95% confidence interval 55-98%)(p < 0.025), malaria in-patient cases by 78% (48-90%), and parasitologically-confirmed malaria out-patient cases [...] BACKGROUND: In Zanzibar, the Ministry of Health and partners...