The relative contribution of climate variability and vector control coverage to changes in malaria parasite prevalence in Zambia 2006-2012 (Publications)
BACKGROUND: Four malaria indicator surveys (MIS) were conducted in Zambia between 2006 and 2012 to evaluate malaria control scale-up. Nationally, coverage of insecticide-treated nets (ITNs) and indoor [...] on malaria parasite prevalence over this period. METHODS: Nationally-representative MISs were conducted in April-June of 2006, 2008, 2010 and 2012 to collect household-level information on malaria control [...] between IRS and ITN coverage and climate variability and malaria parasite...
Severe malaria in Europe: an 8-year multi-centre observational study (Publications)
lly confirmed severe Plasmodium falciparum malaria according to the 2006 WHO criteria. RESULTS: From 2006 to 2014 a total of 185 patients with severe malaria treated in 12 European countries were included [...] patients with severe malaria in this study were tourists or migrants acquiring the infection in West Africa. Intravenous artesunate is increasingly used for treatment of severe malaria in many European treatment [...] BACKGROUND: Malaria remains one of the most serious infections for...
Structure of the malaria vaccine candidate antigen CyRPA and its complex with a parasite invasion inhibitory antibody (Publications)
Invasion of erythrocytes by Plasmodial merozoites is a composite process involving the interplay of several proteins. Among them, the Plasmodium falciparum Cysteine-Rich Protective Antigen (PfCyRPA) i
Community-based surveillance to monitor mortality in a malaria-endemic and Ebola-epidemic setting in rural Guinea (Publications)
a reinforced malaria control program and one sous-prefecture without (Koundou) in Guinea. Deaths were recorded by key informants and classified as due to malaria or another cause. Malaria deaths were those [...] deaths were reported from July 2011-June 2014, of which 55.2% (N = 686) were reported as due to malaria. Malaria-attributable proportional mortality decreased by 26.5% (95% confidence interval [CI] = 13.9-33 [...] those reported as due to malaria or fever in the 3 days before death with...
Malaria intervention scale-up in Africa: effectiveness predictions for health programme planning tools, based on dynamic transmission modelling (Publications)
(IRS), management of uncomplicated malaria cases (CM) and seasonal malaria chemoprophylaxis (SMC) over a 10-year horizon, over a range of settings with stable endemic malaria. Generalized linear regression [...] intervention impact, to inform a malaria module in the Spectrum health programme planning tool. METHODS: The dynamic Plasmodium falciparum transmission model OpenMalaria was used to simulate health effects [...] entail a partial rebound in malaria mortality among people above 5 years of...
Public health impact and cost-effectiveness of the RTS,S/AS01 malaria vaccine: a systematic comparison of predictions from four mathematical models (Publications)
BACKGROUND: The phase 3 trial of the RTS,S/AS01 malaria vaccine candidate showed modest efficacy of the vaccine against Plasmodium falciparum malaria, but was not powered to assess mortality endpoints [...] settings. Decisions about implementation will need to consider levels of malaria burden, the cost-effectiveness and coverage of other malaria interventions, health priorities, financing, and the capacity of the [...] iveness of routine use of the RTS,S/AS01 vaccine in African settings....
Susceptibility of <em>Anopheles gambiae</em> to insecticides used for malaria vector control in Rwanda (Publications)
a major threat to the gains made in malaria control. To monitor the presence and possible emergence of resistance against a variety of insecticides used for malaria control in Rwanda, nationwide insecticide [...] using the synergist PBO. CONCLUSION: This is the first nationwide study of insecticide resistance in malaria vectors in Rwanda. It shows the gradual increase of insecticide resistance to pyrethroids (lambd [...] testing and implement an insecticide resistance management strategy to...