The Internet: a valuable tool for Roll Back Malaria (Publications)
Roll Back Malaria (RBM) will face a tremendous challenge in halving the current malaria burden by 2010. Thus, the initiative needs to explore novel and innovative approaches. The potential of the Internet [...] build a virtual community and to facilitate the training of a new generation of skilled personel for malaria diagnosis is discussed here. We also argue that investment in information technology is crucial to
<em>Falciparum </em>malaria presenting with pruritic rashes (Publications)
Rash is not generally believed to be a symptom of malaria. Two cases of acute falciparum malaria in non-immune residents of Mozambique who presented with pruritic rashes are reported. One case exhibited [...] Review of the literature reveals cases of malaria from India, East Africa, France, and the USA presenting with urticaria or a pruritic rash. Previous exposure to malaria may be a factor in these presentations [...] ns. Physicians should not discount the diagnosis of malaria in patients with...
The economic payoffs of integrated malaria control in the Zambian copperbelt between 1930 and 1950 (Publications)
suggested that malaria is delaying the economic development of countries that are most severely affected by the disease. Several studies have documented the economic consequences of malaria at the household [...] economic impact of malaria on the industrial and service sectors that will probably become the backbone of many developing economies. We estimate the economic effects of integrated malaria control implemented [...] 284 malaria attacks and 942,347 work shift losses were averted. Overall,...
A <em>var</em> gene promoter controls allelic exclusion of virulence genes in <em>Plasmodium falciparum</em> malaria (Publications)
proteins. In the apicomplexan parasite Plasmodium falciparum, responsible for the severe form of malaria in humans, this is exemplified by antigenic variation of the highly polymorphic P. falciparum erythrocyte
Optimized Malaria-antigens delivered by immunostimulating reconstituted influenza virosomes (Publications)
Malaria remains a serious cause of morbidity and mortality in millions of individuals each year. The development of widespread resistance of the parasite to drugs as well as resistance of the transmitting [...] transmitting mosquito-vector to insecticides in combination with the poor economic situation of many malaria-endemic countries make the development of an effective and inexpensive treatment and prevention a main [...] appropriate conformation. Here, we review the development of a new...
Synthetic glycosylphosphatidylinositol microarray reveals differential antibody levels and fine specificities in children with mild and severe malaria (Publications)
Plasmodium falciparum life cycle are a central toxin in malaria. The contribution of GPI specific humoral immune responses to protection against malaria pathology is not clear, since studies on the correlation [...] anti-GPI antibody responses in healthy and malaria diseased individuals. Furthermore, the age dependent development of humoral immune responses against GPI in malaria-exposed children was investigated. Anti-GPI [...] with severe malaria and healthy children contained antibodies that...
Tolerability and efficacy of a pediatric granule formulation of artesunate-mefloquine in young children from Cameroon with uncomplicated falciparum... (Publications)
developed. In this open, non-comparative study in Cameroonian children with uncomplicated falciparum malaria, the safety and efficacy of this formulation was tested, with a particular emphasis on the risk of