Critical evaluation of molecular monitoring in malaria drug efficacy trials and pitfalls of length-polymorphic markers (Publications)
therefore calls for necessary amendments to the current WHO recommendations for PCR correction of malaria drug trial endpoints. Accuracy of genotyping outcomes could be improved by separate amplification
Mapping hotspots of malaria transmission from pre-existing hydrology, geology and geomorphology data in the pre-elimination context of Zanzibar,... (Publications)
BackgroundLarval source management strategies can play an important role in malaria elimination programmes, especially for tackling outdoor biting species and for eliminating parasite and vector populations [...] larval source management requires tools for identifying geographic foci of vector proliferation and malaria transmission where these efforts may be concentrated. Previous studies have relied on surface topographic [...] examine the relationship between dry and wet season spatial...
Estimating malaria burden in Nigeria: a geostatistical modelling approach (Publications)
This study has produced a map of malaria prevalence in Nigeria based on available data from the Mapping Malaria Risk in Africa (MARA) database, including all malaria prevalence surveys in Nigeria that [...] correlating with malaria presence were land surface temperature for day and rainfall. It was also found that malaria prevalence increased with distance to water bodies up to 4 km. The malaria risk map estimated [...] low malaria prevalence were found to be scattered around the country with...
Structural and functional characterisation of the toll like receptor 9 of <em>Aotus nancymaae</em>, a non-human primate model for malaria vaccine... (Publications)
In the absence of suitable rodent animal models for Plasmodium falciparum malaria, the efficacy testing of asexual blood-stage vaccine candidates in Aotus nancymaae represents a tool to select between [...] sequence conservation of Aona-TLR-9 reinforces the suitability of A. nancymaae as animal model for malaria subunit vaccine development
Cytochrome P450 6M2 from the malaria vector <em>Anopheles gambiae</em> metabolizes pyrethroids: sequential metabolism of deltamethrin revealed (Publications)
Resistance to pyrethroid insecticides in the malaria vector Anopheles gambiae is a major threat to malaria control programmes. Cytochome P450-mediated detoxification is an important resistance mechanism [...] metabolic resistance to pyrethroids and thus an important target for the design of new tools to combat malaria
Monitoring of larval habitats and mosquito densities in the Sudan savanna of Mali: implications for malaria vector control (Publications)
the rainy season, vector control in this small hamlet may be a cost-effective way to ameliorate malaria transmission in the 40-times larger village
Spatial analysis of malaria transmission parameters in the rice cultivation area of office du Niger, Mali (Publications)
The effects of rice growth environment on malaria transmission, taking into account spatial correlation, were assessed in the Office du Niger, Mali. Between April 1999 to January 2001, 8 quarterly entomologic [...] and showed low spatial correlations (up to 3.4 km), which suggested that small area variation in malaria transmission results mainly from variations in vector-human contact. Control strategies in rice