Infection of organotypic slice cultures from rat central nervous tissue with <em>Trypanosoma brucei brucei</em> (Publications)
We recently described a new procedure to grow nervous tissue as organotypic culture. The main feature of these slice cultures is to maintain a well preserved, three-dimensional organisation of the cen
Trypanocidal activity of melamine-based nitroheterocycles (Publications)
A series of nitroheterocyclic compounds were designed with linkages to melamine or benzamidine groups that are known substrates of the P2 aminopurine and other transporters in African trypanosomes of
Rethinking Th2 antibody responses and allergic sensitization (Publications)
Human Th2 cytokines (interleukins 4 and 13) induce co-expression of IgE and IgG4 through sequential switching. The regulation of IgG4 responses and the role of these responses in the pathogenesis of a
Field efficacy of thermally expelled or live potted repellent plants against African malaria vectors in western Kenya (Publications)
OBJECTIVE: To estimate the effectiveness of live potted plants and thermal expulsion of plant materials in repelling African malaria vectors in traditional houses in western Kenya. METHODS: Ocimum ame
Antiprotozoal polyacetylenes from the Tanzanian medicinal plant <em>Cussonia zimmermannii</em> (Publications)
From the petroleum ether extract of the root bark of Cussonia zimmermannii four polyacetylenes, 1- 4, were isolated, three of which ( 1- 3) were active against Trypanosoma brucei rhodesiense, Trypanos
Antimalarial activity of novel pyrrolizidinyl derivatives of 4-aminoquinoline (Publications)
Two pyrrolizidinylalkyl derivatives of 4-amino-7-chloroquinoline (MG2 and MG3) were prepared and tested in vitro against CQ-sensitive and CQ-resistant strains of Plasmodium falciparum and in vivo in a
