Chloropupukeanolides C-E: cytotoxic pupukeanane chlorides with a spiroketal skeleton from <em>Pestalotiopsis fici</em> (Publications)
Chloropupukeanolides C-E (8-10), three highly functionalized secondary metabolites featuring a novel spiroketal skeleton derived from the chlorinated tricyclo-[4.3.1.0(3, 7) ]-decane (pupukeanane) and
Human susceptibility to <em>Schistosoma japonicum</em> in China correlates with antibody isotypes to native antigens (Publications)
Antibody isotypic responses (IgE, IgA, IgG1, IgG2, IgG3 and IgG4) to Schistosoma japonicum antigens--adult worm (AWA), soluble egg (SEA) and the recombinant proteins TEG (22.6-kDa tegumental antigen,
Alcohol and smoking in relation to the prevalence of adenomatous colorectal polyps detected at sigmoidoscopy (Publications)
Cigarette smoking has been associated with adenomatous polyps of the large bowel but not with increased risk of colorectal cancer. Giovannucci et al recently proposed a hypothesis to explain this inco
Decreased in vitro susceptibility of <em>Plasmodium falciparum</em> isolates to artesunate, mefloquine, chloroquine, and quinine in Cambodia from 2001... (Publications)
This study describes the results of in vitro antimalarial susceptibility assays and molecular polymorphisms of Plasmodium falciparum isolates from Cambodia. The samples were collected from patients en
Early age at menarche, lung function and adult asthma (Publications)
RATIONALE: Hormonal and metabolic status appears to influence lung health in women, and there are findings suggesting that early menarche may be related to asthma, cardiovascular disease, diabetes and
Morphological effects and tegumental alterations induced by mefloquine on schistosomula and adult flukes of <em>Schistosoma mansoni</em> (Publications)
SUMMARYThere is a pressing need to develop novel anti-schistosomal drugs, as current treatment relies largely on praziquantel (PZQ). To further strengthen current evidence of the anti-schistosomal pro