In vitro and in vivo characterization of the antimalarial lead compound SSJ-183 in <em>Plasmodium</em> models (Publications)
The objective of this work was to characterize the in vitro (Plasmodium falciparum) and in vivo (Plasmodium berghei) activity profile of the recently discovered lead compound SSJ-183. The molecule sho
Development of a glycoconjugate vaccine to prevent meningitis in Africa caused by meningococcal serogroup X (Publications)
Neisseria meningitidis is a major cause of bacterial meningitis worldwide, especially in the African meningitis belt, and has a high associated mortality. The meningococcal serogroups A, W, and X have
Trachoma among children in community surveys from four African countries and implications of using school surveys for evaluating prevalence (Publications)
BACKGROUND: School surveys provide a convenient platform to obtain large child cohorts from multiple communities and are widely used as a proxy to determine community prevalence of neglected tropical
Challenging sleep homeostasis in narcolepsy-cataplexy: implications for non-REM and REM sleep regulation (Publications)
STUDY OBJECTIVES: We recently proposed insufficient non-rapid eye movement sleep (NREMS) intensity to contribute to disturbed nocturnal sleep in patients with narcolepsy-cataplexy (NC). To test this h
Characterization of a serine hydrolase targeted by acyl-protein thioesterase inhibitors in <em>Toxoplasma gondii</em> (Publications)
In eukaryotic organisms, cysteine palmitoylation is an important reversible modification that impacts protein targeting, folding, stability, and interactions with partners. Evidence suggests that prot
Out-of-Africa migration and neolithic coexpansion of <em>Mycobacterium tuberculosis</em> with modern humans (Publications)
Tuberculosis caused 20% of all human deaths in the Western world between the seventeenth and nineteenth centuries and remains a cause of high mortality in developing countries. In analogy to other cro
Diagnosis and treatment of schistosomiasis in children in the era of intensified control (Publications)
In the current era of intensified and integrated control against schistosomiasis and other neglected tropical diseases, there is a need to carefully rethink and take into consideration disease-specifi