Structure-activity relationship studies on thiaplidiaquinones A and B as novel inhibitors of <em>Plasmodium falciparum</em> and farnesyltransferase (Publications)
Marine meroterpenoids, thiaplidiaquinones A and B and their respective non-natural dioxothiazine regioisomers have been shown to inhibit mammalian and protozoal farnesyltransferase (FTase) with the re
Biologie et élevage de la mouche tsé-tsé (Glossina palpalis) [16mm film] (Publications)
Tsetse-Fliegen als Überträger der Schlafkrankheit sind für die Tropenmedizin von grosser Wichtigkeit. Gezeigt werden Habitus, Haltung der Fliegen in Netzkäfigen, Fütterung mit Blut von lebenden Meersc
Genes and pathways underlying susceptibility to impaired lung function in the context of environmental tobacco smoke exposure (Publications)
BACKGROUND: Studies aiming to assess genetic susceptibility for impaired lung function levels upon exposure to environmental tobacco smoke (ETS) have thus far focused on candidate-genes selected based
<em>In vitro</em> and<em> in vivo</em> activity of R- and S-praziquantel enantiomers and the main human metabolite trans-4-hydroxy-praziquantel... (Publications)
BACKGROUND: Praziquantel (PZQ) is the mainstay of schistosomiasis control and has been successfully used for decades. However, its mechanism of action is not fully understood. While the majority of st
Bifurcatriol, a new antiprotozoal acyclic diterpene from the brown alga <em>Bifurcaria bifurcata</em> (Publications)
Linear diterpenes that are commonly found in brown algae are of high chemotaxonomic and ecological importance. This study reports bifurcatriol (1), a new linear diterpene featuring two stereogenic cen