Potent antimalarials with development potential identified by structure-guided computational optimization of a pyrrole-based dihydroorotate... (Publications)
Dihydroorotate dehydrogenase (DHODH) has been clinically validated as a target for the development of new antimalarials. Experience with clinical candidate triazolopyrimidine DSM265 (1) suggested that
Repositioning and characterization of 1-(pyridin-4-yl)pyrrolidin-2-one derivatives as <em>Plasmodium </em>cytoplasmic prolyl-trna synthetase... (Publications)
Prolyl-tRNA synthetase (PRS) is a clinically validated antimalarial target. Screening of a set of PRS ATP-site binders, initially designed for human indications, led to identification of 1-(pyridin-4-
Health in food systems policies in India: a document review (Publications)
BACKGROUND: Food systems affect nutritional and other health outcomes. Recent literature from India has described policy aspects addressing nutritional implications of specific foods (eg, fruits, vege
Human behavior, livelihood, and malaria transmission in two sites of Papua New Guinea (Publications)
BACKGROUND: Malaria transmission is currently resurging in Papua New Guinea (PNG). In addition to intervention coverage, social and cultural factors influence changes in epidemiology of malaria in PNG
Towards elimination of mother-to-child transmission of HIV in Rwanda: a nested case-control study of risk factors for transmission (Publications)
BACKGROUND: Mother-to-child HIV transmission (MTCT) has substantially declined since the scale-up of prevention programs around the world, including Rwanda. To achieve full elimination of MTCT, it is
The complexity of scaling up an mHealth intervention: the case of SMS for Life in Tanzania from a health systems integration perspective (Publications)
BACKGROUND: SMS for Life was one of the earliest large-scale implementations of mHealth innovations worldwide. Its goal was to increase visibility to antimalarial stock-outs through the use of SMS tec
Search for the active ingredients from a 2-aminothiazole DMSO stock solution with antimalarial activity (Publications)
Chemical decomposition of DMSO stock solutions is a common incident that can mislead biological screening campaigns. Here, we share our case study of 2-aminothiazole 1, originating from an antimalaria
The consequences of compromising the EU's free movement of persons principle on Swiss research: how to survive constrained access to regional... (Publications)
Between 2014 and 2016, Switzerland's access to some of the EU funding was limited after a referendum against mass immigration was accepted and the country refused to sign the free movement accord to t
Kangaroo mother care for preterm infants and child development: evidence from São Paulo, Brazil (Publications)
Globally, an estimated 15 million children are born prematurely each year, resulting in a high burden of under-five mortality and neurodevelopmental disability. Kangaroo Mother Care (KMC) is a key int