Efficacy, metabolism and pharmacokinetics of Ro 15-5458, a forgotten schistosomicidal 9-acridanone hydrazone (Publications)
BACKGROUND: Treatment of schistosomiasis, a neglected disease, relies on just one partially effective drug, praziquantel. We revisited the 9-acridanone hydrazone, Ro 15-5458, a largely forgotten antis
Characteristics of persistent hotspots of <em>Schistosoma mansoni</em> in western Côte d'Ivoire (Publications)
BACKGROUND: Preventive chemotherapy with praziquantel is the cornerstone of schistosomiasis control. However, in some social-ecological settings, the prevalence and/or intensity of Schistosoma infecti
Acceptability of a prime vendor system in public healthcare facilities in Tanzania (Publications)
BACKGROUND: Pharmaceutical supply chain management in low- and middle-income countries has received substantial attention to address the shortage of medicines at peripheral facilities. The focus has b
The impact of maternal RSV vaccine to protect infants in Gavi-supported countries: estimates from two models (Publications)
BACKGROUND: Interventions to protect young infants against respiratory syncytial virus (RSV) are in advanced phases of development and are expected to be available in the foreseeable future. Gavi, the
Vaccine implementation factors affecting maternal tetanus immunization in low- and middle-income countries: results of the Maternal Immunization and... (Publications)
OBJECTIVES: To examine the characteristics of existing maternal tetanus immunization programmes for pregnant women in low- and middle-income countries (LMICs) and to identify and understand the challe
Development of an ELISA for the quantification of mycolactone, the cytotoxic macrolide toxin of <em>Mycobacterium ulcerans</em> (Publications)
Mycolactones, macrolide cytotoxins, are key virulence factors of Mycobacterium ulcerans, the etiological agent of the chronic necrotizing skin disease Buruli ulcer. There is urgent need for a simple p
Evaluation of different methods and data sources to optimise modelling of NO2 at a global scale (Publications)
BACKGROUND: In countries where air pollution stations are unavailable or scarce, station measurements from other countries and atmospheric remote sensing could jointly provide information to estimate