A high-throughput cell- and virus-free assay shows reduced neutralization of SARS-CoV-2 variants by COVID-19 convalescent plasma (Publications)
The detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-specific antibodies in the serum of an individual indicates prior infection or vaccination. However, it provides limited i
Common haplotypes at the <em>CFH </em>locus and low-frequency variants in <em>CFHR2 </em>and <em>CFHR5 </em>associate with systemic FHR concentrations... (Publications)
Age-related macular degeneration (AMD) is the principal cause of blindness in the elderly population. A strong effect on AMD risk has been reported for genetic variants at the CFH locus, encompassing
Two-target quantitative PCR to predict library composition for shallow shotgun sequencing (Publications)
When determining human microbiota composition, shotgun sequencing is a powerful tool that can generate high-resolution taxonomic and functional information at once. However, the technique is limited b
Quantifying transmission fitness costs of multi-drug resistant tuberculosis (Publications)
As multi-drug resistant tuberculosis (MDR-TB) continues to spread, investigating the transmission potential of different drug-resistant strains becomes an ever more pressing topic in public health. Wh
Associations of air pollution and greenness with the nasal microbiota of healthy infants: a longitudinal study (Publications)
BACKGROUND: Air pollution and greenness are associated with short- and long-term respiratory health in children but the underlying mechanisms are only scarcely investigated. The nasal microbiota durin
Mortality from drug-resistant tuberculosis in high-burden countries comparing routine drug susceptibility testing with whole-genome sequencing: a... (Publications)
Background: Drug resistance threatens global tuberculosis control. We aimed to examine mortality in patients with tuberculosis from high-burden countries, according to concordance or discordance of re
Early whole blood transcriptional responses to radiation-attenuated <em>Plasmodium falciparum</em> sporozoite vaccination in malaria naive and malaria... (Publications)
BACKGROUND: Vaccination with radiation-attenuated Plasmodium falciparum sporozoites is known to induce protective immunity. However, the mechanisms underlying this protection remain unclear. In this w
Global, regional, and national burden of mortality associated with non-optimal ambient temperatures from 2000 to 2019: a three-stage modelling study (Publications)
BACKGROUND: Exposure to cold or hot temperatures is associated with premature deaths. We aimed to evaluate the global, regional, and national mortality burden associated with non-optimal ambient tempe
<em>Mycobacterium tuberculosis </em>complex lineage 5 exhibits high levels of within-lineage genomic diversity and differing gene content compared to... (Publications)
Pathogens of the Mycobacterium tuberculosis complex (MTBC) are considered to be monomorphic, with little gene content variation between strains. Nevertheless, several genotypic and phenotypic factors