Evaluation of standard field and laboratory methods to compare protection times of the topical repellents PMD and DEET (Publications)
in the AIC test were 0.5, 2 and 2 hours against Ae. aegypti, An. stephensi and Cx. quinquefasciatus, respectively, and the corresponding median CPTs for PMD were 0.5, 1 and 0.5 hours. In conclusion, DEET
A switch in regulatory T cells through farm-exposure during immune maturation in childhood (Publications)
BACKGROUND: Farm exposure protects against development of allergies early in life. At 4.5 years, protection against asthma by farm-milk exposure was partially mediated by regulatory T-cells (Tregs). The [...] effect via Tregs during childhood immune maturation. METHODS: Tregs were assessed longitudinally at 4.5 and 6 years in 111 children (56 farm, 55 reference children) from the PASTURE/EFRAIM birth cohort ( [...] Treg percentage before and after stimulation and FOXP3 mRNA-expression ex vivo...
Spatial-temporal and cancer risk assessment of selected hazardous air pollutants in Seattle (Publications)
HAPs. The median values of the estimated inhalation cancer risks ranged between 4.3x10(-5) and 6.0x10(-5), with the 5th and 95th percentile levels exceeding the 1 in a million level. VOCs as a whole contributed
Transmission dynamics of highly pathogenic avian influenza at lake constance (Europe) during the outbreak of winter 2005-2006 (Publications)
Highly pathogenic avian influenza virus (HPAI) H5N1 poses a serious threat to domestic animals. Despite the large number of studies on influenza A virus in waterbirds, little is still known about the [...] and spread of these viruses in the wild waterbird population. From January to April 2006, the HPAI H5N1 virus was confirmed in 82 dead wild waterbirds at the shores of Lake Constance. In this study, we [...] at the end of the winter. With this study, we quantify for the first time the...
Metabolic profiling framework for discovery of candidate diagnostic markers of malaria (Publications)
metabolites (i) 4-amino-1-[3-hydroxy-5-(hydroxymethyl)-2,3-dihydrofuran-2-yl]pyrimidin-2(1H)-one, (ii) 2-amino-4-({[5-(4-amino-2-oxopyrimidin-1(2H)-yl)-4-hydroxy-4,5-dihydrofuran-2-yl] methyl}sulfanyl)butanoic
Randomised trial of SPf66 vaccine against <em>Plasmodium falciparum</em> malaria in children in southern Tanzania (Publications)
each under-5 child suffers on average 3 clinical fever episodes per year. Minimum estimated community rates for serious malaria (cerebral malaria or malaria and anaemia) affect approximatively 5% of all children [...] conditions of a field experiment, the annual incidence of a febrile illness (axillary temperature > or = 37.5 degrees C) reported to the curative primary health services in each child was 0.86 of which 0,35 can
8,8-dialkyldihydroberberines with potent antiprotozoal activity (Publications)
brucei bloodstream forms. For example, 8,8-diethyldihydroberberine chloride (5b) exhibited in vitro IC(50) values of 77, 100, and 5.3 nM against these three parasites, respectively. In turn, two 8,8-dialk [...] of visceral leishmaniasis and African trypanosomiasis, with 8,8-dimethyldihydroberberine chloride (5a) reducing liver parasitemia by 46% in L. donovani-infected BALB/c mice when given at an intraperitoneal
Spatial-temporal and cancer risk assessment of selected hazardous air pollutants in Seattle (Publications)
HAPs. The median values of the estimated inhalation cancer risks ranged between 4.3x10(-5) and 6.0x10(-5), with the 5th and 95th percentile levels exceeding the 1 in a million level. VOCs as a whole contributed
Transmission dynamics of highly pathogenic avian influenza at lake constance (Europe) during the outbreak of winter 2005-2006 (Publications)
Highly pathogenic avian influenza virus (HPAI) H5N1 poses a serious threat to domestic animals. Despite the large number of studies on influenza A virus in waterbirds, little is still known about the [...] and spread of these viruses in the wild waterbird population. From January to April 2006, the HPAI H5N1 virus was confirmed in 82 dead wild waterbirds at the shores of Lake Constance. In this study, we [...] at the end of the winter. With this study, we quantify for the first time the...
8,8-dialkyldihydroberberines with potent antiprotozoal activity (Publications)
brucei bloodstream forms. For example, 8,8-diethyldihydroberberine chloride (5b) exhibited in vitro IC(50) values of 77, 100, and 5.3 nM against these three parasites, respectively. In turn, two 8,8-dialk [...] of visceral leishmaniasis and African trypanosomiasis, with 8,8-dimethyldihydroberberine chloride (5a) reducing liver parasitemia by 46% in L. donovani-infected BALB/c mice when given at an intraperitoneal