Metabolic profiling framework for discovery of candidate diagnostic markers of malaria (Publications)
metabolites (i) 4-amino-1-[3-hydroxy-5-(hydroxymethyl)-2,3-dihydrofuran-2-yl]pyrimidin-2(1H)-one, (ii) 2-amino-4-({[5-(4-amino-2-oxopyrimidin-1(2H)-yl)-4-hydroxy-4,5-dihydrofuran-2-yl] methyl}sulfanyl)butanoic
8,8-dialkyldihydroberberines with potent antiprotozoal activity (Publications)
brucei bloodstream forms. For example, 8,8-diethyldihydroberberine chloride (5b) exhibited in vitro IC(50) values of 77, 100, and 5.3 nM against these three parasites, respectively. In turn, two 8,8-dialk [...] of visceral leishmaniasis and African trypanosomiasis, with 8,8-dimethyldihydroberberine chloride (5a) reducing liver parasitemia by 46% in L. donovani-infected BALB/c mice when given at an intraperitoneal
A switch in regulatory T cells through farm-exposure during immune maturation in childhood (Publications)
BACKGROUND: Farm exposure protects against development of allergies early in life. At 4.5 years, protection against asthma by farm-milk exposure was partially mediated by regulatory T-cells (Tregs). The [...] effect via Tregs during childhood immune maturation. METHODS: Tregs were assessed longitudinally at 4.5 and 6 years in 111 children (56 farm, 55 reference children) from the PASTURE/EFRAIM birth cohort ( [...] Treg percentage before and after stimulation and FOXP3 mRNA-expression ex vivo...
Effects of Low-Level Air Pollution: A study in Europe (Projects)
https://www.swisstph.ch/en/projects/project-detail/project/effects-of-low-level-air-pollution-a-study-in-europe
(> 35 million subjects). The analysis focuses on the pollutants PM2.5 (fine particles with an aerodynamic diameter of less than 2.5 μm), nitrogen dioxide (NO2), and ozone (O3), but also exploits the rich [...] collaboration in a research project Mortality and morbidity effects of long-term exposure to low-level PM2.5, Black Carbon, NO2 and O3: an analysis of European cohorts. The Project addresses the issue of health
Evaluation of standard field and laboratory methods to compare protection times of the topical repellents PMD and DEET (Publications)
in the AIC test were 0.5, 2 and 2 hours against Ae. aegypti, An. stephensi and Cx. quinquefasciatus, respectively, and the corresponding median CPTs for PMD were 0.5, 1 and 0.5 hours. In conclusion, DEET
Antiprotozoal germacranolide sesquiterpene lactones from <em>Tanacetum sonbolii</em> (Publications)
rhodesiense and cytotoxicity against rat myoblast (L6) cells were determined. Compounds 4: and 5: showed IC50 values of 5.1 and 10.2 microM and selectivity indices of 3.9 and 4.0, respectively.
Hydrangenone, a new isoprenoid with an unprecedented skeleton from <em>Salvia hydrangea</em> (Publications)
Hydrangenone, a new heptacyclic isoprenoid with a 6/7/6/5/5 membered carbon ring skeleton, was isolated from the aerial parts of Salvia hydrangea. The structure was established by extensive NMR spectroscopic
Antimicrobial prophylaxis to prevent surgical site infections in a rural sub-Saharan hospital (Publications)
SSI rate of 22% was high. Most (88%) of the patients received prophylaxis after incision, and only 5% within the 30-min period before incision. Of all pathogens isolated from SSIs, 60% were resistant to [...] aminopenicillins (23%) and benzylpenicillin (15%). Staphylococcus aureus (36%), Escherichia coli (5%) and enterococci (4%) were the pathogens isolated most commonly from SSIs
Hydrangenone, a new isoprenoid with an unprecedented skeleton from <em>Salvia hydrangea</em> (Publications)
Hydrangenone, a new heptacyclic isoprenoid with a 6/7/6/5/5 membered carbon ring skeleton, was isolated from the aerial parts of Salvia hydrangea. The structure was established by extensive NMR spectroscopic
Antimicrobial prophylaxis to prevent surgical site infections in a rural sub-Saharan hospital (Publications)
SSI rate of 22% was high. Most (88%) of the patients received prophylaxis after incision, and only 5% within the 30-min period before incision. Of all pathogens isolated from SSIs, 60% were resistant to [...] aminopenicillins (23%) and benzylpenicillin (15%). Staphylococcus aureus (36%), Escherichia coli (5%) and enterococci (4%) were the pathogens isolated most commonly from SSIs