Synthesis and in vitro antiprotozoal activities of 5-phenyliminobenzo[a]phenoxazine derivatives (Publications)
donovani and Trypanosoma brucei rhodesiense. N,N-Diethyl-5-((4-methoxyphenyl)imino)-5H-benzo[a]phenoxazin-9-amine shows IC(50)=0.040mumolL(-1) with a selective index of 1425 against Plasmodium falciparum K1 [...] A series of 5-phenyliminobenzo[a]phenoxazine derivatives were synthesized. The in vitro antiprotozoal activities were evaluated against Plasmodium falciparum K1, Trypanosoma cruzi, Leishmania donovani
Associations between infections and clinical outcome parameters in status epilepticus: a retrospective 5-year cohort study (Publications)
ICU stay (p = 0.0041), higher risk of RSE (odds ratio [OR] 4.8, p = 0.0002), and higher mortality (OR 5.2, p = 0.0003) than those without infectious complications. Infections during the first 3 days after
The activity of diguanidino and 'reversed' diamidino 2,5-diarylfurans versus <em>Trypanosoma cruzi</em> and <em>Leishmania donovani</em> (Publications)
The in vitro activity of 20 dicationic molecules containing either diguanidino or reversed amidine cationic groups were evaluated versus Trypanosoma cruzi and Leishmania donovani. The most active comp
Modified 5'-trityl nucleosides as inhibitors of <em>Plasmodium falciparum</em> dUTPase (Publications)
discovery of 5'-tritylated analogues of deoxyuridine as selective inhibitors of this Plasmodium falciparum enzyme. Herein we report further structure-activity studies; in particular, variations of the 5'-trityl [...] ons of the base. Compounds were tested against both the enzyme and the parasite. Variations of the 5'-trityl group and of the 3'-substituent were well tolerated and yielded active compounds. However, there
Elemental composition and oxidative properties of PM2.5 in Estonia in relation to origin of air masses - results from the ECRHS II in Tartu (Publications)
Fine particulate matter (PM(2.5)) was sampled at an urban background site in Tartu, Estonia over one-year period during the ECRHS II study. The elemental composition of 71PM(2.5) samples was analyzed for different [...] oxidative properties were correlated to the origin of air masses. The OH values were approximately 1.5 times higher when air masses originated from the direction of "Eastern Europe" or "Russia." The origin [...] measured particles was evaluated using principal component factor...
Antitrypanosomal activity of 5-nitro-2-aminothiazole-based compounds (Publications)
A small series of 5-nitro-2-aminothiazole-based amides containing arylpiperazine-, biphenyl- or aryloxyphenyl groups in their core were synthesized and evaluated as antitrypanosomatid agents. All tested
Efficacy of the novel diamidine compound 2,5-Bis(4-amidinophenyl)- furan-bis-<em>O</em>-Methlylamidoxime (Pafuramidine, DB289) against <em>Trypanosoma... (Publications)
consecutive days. The animals in groups 4 and 5 were treated with 10 mg/kg for 10 consecutive days starting on the 14th day p.i. (group 4) or on the 28th day p.i. (group 5), when these animals were in the late [...] of three (group 5) monkeys. These studies demonstrated that pafuramidine was orally active in monkeys with early-stage T. brucei rhodesiense infections at dose rates above 3 mg/kg for 5 days. It was also [...] treatment with parenterally administered medicines. The efficacy of a...
Validation of a questionnaire to assess dietary habits among 5-13-year old school children of farmers and anthroposophic families (Publications)
Objective. To evaluate dietary habits among 5-13-year old school children of farmers, anthroposophic families and controls and to evaluate the validity of a food questionnaire as part of a lifestyle q
