Transcriptomic and lipidomic profiles of glycerolipids during <em>Arabidopsis</em> flower development (Publications)
system to synchronize flower development in Arabidopsis. The transgenic plant PAP1::AP1-GR ap1-1 cal-5 showed synchronized flower development upon dexamethasone treatment, which enabled massive harvesting [...] nonphosphorous galactolipids during the late stage. Moreover, in the midstage, phosphatidylinositol 4,5-bisphosphate concentration was increased transiently, which suggests the stimulation of the phosphoinositide [...] of multiple phosphoinositide biosynthetic genes associated with the...
Socioeconomic disparities in childhood cancer survival in Switzerland (Publications)
nervous system (CNS) tumors); with an overall 5-year survival of 77% (95%CI 75-79%). Higher SES, particularly parents' education, was associated with a lower 5-year cumulative mortality. Results varied by [...] (parental education, living condition, area-based SES). Using Cox proportional hazards models, we analyzed 5-year cumulative mortality in all patients registered in the Swiss Childhood Cancer Registry diagnosed
Modelling the health and economic impacts of the elimination of river blindness (onchocerciasis) in Africa (Publications)
$37.2 million-$39.9 million and out-of-pocket payments by $25.5 million-$26.9 million over 2013-2045, and generate economic benefits up to $5.9 billion-$6.4 billion in terms of income gains. DISCUSSION: [...] terms of income gains. RESULTS: The elimination of onchocerciasis in Africa would avert 4.3 million-5.6 million disability-adjusted life years over 2013-2045 when compared with staying in the control mode
Evaluation of land use regression models for NO2 and particulate matter in 20 European study areas: the ESCAPE project (Publications)
correlation between concentrations of PM metrics and NO2. LUR models have been developed for NO2, PM2.5 absorbance and Copper (Cu) in PM10 based on 20 sites in each of the 20 study areas of the ESCAPE project [...] concentrations with measured NO2 concentrations at the 20 additional NO2 sites in each area. For NO2, PM2.5 absorbance and PM10 Cu, the median LOOCV R2s were 0.83, 0.81 and 0.76 whereas the median HEV R2 were [...] were 0.52, 0.44 and 0.40. There was a positive association between the...
The influence of meteorological factors and atmospheric pollutants on the risk of preterm birth (Publications)
Cox models. The frequency of preterm birth was 5.0%. Preterm birth risk tended to increase with first-trimester average atmospheric pressure (odds ratio per 5-mbar increase = 1.06, 95% confidence interval: [...] some evidence of an increase in preterm birth risk with first-trimester average temperature in the -5 degrees C to 15 degrees C range, with a plateau afterwards (spline coding, P = 0.08). No evidence of
Relative contribution of day-to-day and intra-specimen variation in faecal egg counts of <em>Schistosoma mansoni</em> before and after treatment with... (Publications)
area in Cjte d'Ivoire highly endemic for S. mansoni. Stool specimens were collected over 5 consecutive days, and 5 egg-counts were made in each specimen by the Kato-Katz technique. The point prevalence of [...] of the first sample was 42.7% and the cumulative prevalence after the maximum sampling effort was 88.5%. Using generalized linear mixed models we found that the presence of S. mansoni eggs in a stool sample
Alkanediamide-linked bisbenzamidines are promising antiparasitic agents (Publications)
compounds (5, 6, 11) were evaluated in vivo in mice infected with the drug-sensitive (Lab 110 EATRO and KETRI 2002) or drug-resistant (KETRI 2538 and KETRI 1992) clinical isolates of T. brucei. Compounds 5 and [...] strain (K1). The in vitro cytotoxicity was determined against rat myoblast cells (L6). Seven compounds (5, 6, 10, 11, 12, 14, 15) showed high potency against both strains of T. brucei and P. falciparum with
Tetanus immunisation in geriatric patients with accidental wounds: how much is needed? (Publications)
physicians' records and vaccination documents in 35.7% (5/14). Antitoxin titres > 0.15 IU/ ml were considered protective, giving a seroprevalence of 92.5%. Sensitivities and negative predictive values for tetanus [...] the single booster immunisation the median titre rose from 1.2 to 14.2 IU/ml, in group B from 0.9 to 5.3 IU/ml after the first, and to 9.6 IU/ml after the third tetanus toxoid dose (p
Prospective risk of morbidity in relation to multiplicity of infection with <em>Plasmodium falciparum </em>in Sao Tomé (Publications)
initial cross-sectional survey, 40.5% of individuals were recorded by microscopy as infected with P. falciparum, and by PCR 60.5%, with the maximum prevalence in children aged 5-10 years. PCR-RFLP typing of
Effect of fireworks events on urban background trace metal aerosol concentrations: is the cocktail worth the show? (Publications)
measured in city centre parkland increased local background PM(2.5) concentrations as follows: Sr (x86), K (x26), Ba (x11), Co (x9), Pb (x7), Cu (x5), Zn (x4), Bi (x4), Mg (x4), Rb (x4), Sb (x3), P (x3), Ga (x2) [...] We report on the effect of a major firework event on urban background atmospheric PM(2.5) chemistry, using 24-h data collected over 8 weeks at two sites in Girona, Spain. The firework pollution episode
