The risk of malarial infections and disease in Papua New Guinean children (Publications)
Plasmodium falciparum and P. vivax infections in six months of active follow-up (P. falciparum = 5.00, P. vivax = 5.28), they were 21 times more likely to develop symptomatic P. falciparum malaria (1.17/year) [...] whereas similar reductions in risk with age of P. falciparum infection was only seen for parasitemias > 5,000/microL (AHR = 0.49) and symptomatic episodes (AHR = 0.51). Infection and symptomatic episodes with
Relative contribution of day-to-day and intra-specimen variation in faecal egg counts of <em>Schistosoma mansoni</em> before and after treatment with... (Publications)
area in Cjte d'Ivoire highly endemic for S. mansoni. Stool specimens were collected over 5 consecutive days, and 5 egg-counts were made in each specimen by the Kato-Katz technique. The point prevalence of [...] of the first sample was 42.7% and the cumulative prevalence after the maximum sampling effort was 88.5%. Using generalized linear mixed models we found that the presence of S. mansoni eggs in a stool sample
Effect of fireworks events on urban background trace metal aerosol concentrations: is the cocktail worth the show? (Publications)
measured in city centre parkland increased local background PM(2.5) concentrations as follows: Sr (x86), K (x26), Ba (x11), Co (x9), Pb (x7), Cu (x5), Zn (x4), Bi (x4), Mg (x4), Rb (x4), Sb (x3), P (x3), Ga (x2) [...] We report on the effect of a major firework event on urban background atmospheric PM(2.5) chemistry, using 24-h data collected over 8 weeks at two sites in Girona, Spain. The firework pollution episode
Prospective risk of morbidity in relation to multiplicity of infection with <em>Plasmodium falciparum </em>in Sao Tomé (Publications)
initial cross-sectional survey, 40.5% of individuals were recorded by microscopy as infected with P. falciparum, and by PCR 60.5%, with the maximum prevalence in children aged 5-10 years. PCR-RFLP typing of
Dicationic near-linear biphenyl benzimidazole derivatives as DNA-targeted antiprotozoal agents (Publications)
IC50 values ranging from 0.5 to 23 nM. The compounds showed moderate to good activity in vivo in the STIB900 model for acute African trypanosomiasis. The most active compounds 5b and e gave 3/4 cures on [...] A series of near-linear biphenyl benzimidazole diamidines 5a-h were synthesized from their respective diamidoximes (4a-h), through the bis-O-acetoxyamidoxime, followed by hydrogenation in glacial acetic
Efficacy study of novel diamidine compounds in a <em>Trypanosoma evansi</em> goat model (Publications)
goats was seen in the positive control group treated with diminazene at 5 mg/kg and in the DB 75 and DB 867 groups treated at 2.5 mg/kg. Drug treatment was administered once every second day for a total [...] goats treated with DB 75 at 1.25 mg/kg. DB 1192 was incapable of curing goats at either four-times 2.5 mg/kg or 1.25 mg/kg. Pharmacokinetic analysis clearly demonstrated that the treatment failures of DB
Fleischkonsum und Serum-Cholesterin-Konzentration (Publications)
mean cholesterol concentration was 5.66 mmol/l (218 mg/dl) (95% confidence interval 4.99-6.33 mmol/l) for men, and 5.33 mmol/l (205 mg/dl) (95% confidence interval 4.98-5.68 mmol/l) for women. The association
Seroprevalence of varicella-zoster virus immunoglobulin G antibodies in Swiss adolescents and risk factor analysis for seronegativity (Publications)
as measured by ELISA was 95.5% (95% confidence interval, 94.5 to 96.4). When serum specimens that were indeterminate by ELISA were tested by FAMA, seroprevalence was 96.5% (95% confidence interval, 95
Diagnostic accuracy and case management of clinical malaria in the primary health services of a rural area in south-eastern Tanzania (Publications)
of any density, 25.5% of all children attending the health services had malaria. This yielded a sensitivity of 70.4% (IC95% = 65.9-74.8%) and a specificity of 68.9% (IC95% = 66.2-71.5%). Accordingly, 30 [...] cases left with no antimalarial treatment. Among malaria-diagnosed patients, 10% were underdosed and 10.5% were overdosed. In this area, as in many African rural areas, the low diagnostic accuracy may imply
Evaluation of land use regression models for NO2 and particulate matter in 20 European study areas: the ESCAPE project (Publications)
correlation between concentrations of PM metrics and NO2. LUR models have been developed for NO2, PM2.5 absorbance and Copper (Cu) in PM10 based on 20 sites in each of the 20 study areas of the ESCAPE project [...] concentrations with measured NO2 concentrations at the 20 additional NO2 sites in each area. For NO2, PM2.5 absorbance and PM10 Cu, the median LOOCV R2s were 0.83, 0.81 and 0.76 whereas the median HEV R2 were [...] were 0.52, 0.44 and 0.40. There was a positive association between the...
