Obstacles to prompt and effective malaria treatment lead to low community-coverage in two rural districts of Tanzania (Publications)
87.5% (78.2-93.8) of the fever cases in children and 80.7% (68.1-90.0) in adults were treated with one of the recommended antimalarials (at the time SP, amodiaquine or quinine). However, only 22.5% (13 [...] (13.9-33.2) of the children and 10.5% (4.0-21.5) of the adults received prompt and appropriate antimalarial treatment. Health facility attendance increased the odds of receiving an antimalarial (OR = 7.7)
Spatial distribution of schistosomiasis and treatment needs in sub-Saharan Africa: a systematic review and geostatistical analysis (Publications)
sis and rigorous variable selection to predict infection risk over a grid of 1?155?818 pixels at 5?×?5 km, on the basis of environmental and socioeconomic predictors and to calculate the number of doses [...] suggest that 163 million (95% Bayesian credible interval [CrI] 155 million to 172 million; 18·5%, 17·6-19·5) of the sub-Saharan African population was infected in 2012. Mozambique had the highest prevalence
Obstacles to prompt and effective malaria treatment lead to low community-coverage in two rural districts of Tanzania (Publications)
87.5% (78.2-93.8) of the fever cases in children and 80.7% (68.1-90.0) in adults were treated with one of the recommended antimalarials (at the time SP, amodiaquine or quinine). However, only 22.5% (13 [...] (13.9-33.2) of the children and 10.5% (4.0-21.5) of the adults received prompt and appropriate antimalarial treatment. Health facility attendance increased the odds of receiving an antimalarial (OR = 7.7)
Quality assurance of rapid diagnostic tests for malaria in routine patient care in rural Tanzania (Publications)
of the study team. Ten thousand six hundred fifty (10,650) patients were tested with RDTs, and 51.5% (5,488/10,650) had a positive test result. Blood smear results were available for 3,914 patients, of [...] for P. falciparum malaria. Overall RDT sensitivity was 90.7% (range by facility 85.7-96.5%) and specificity was 73.5% (range 50.0-84.3%). Sensitivity increased with increasing parasite density. Successful
Spatial distribution of schistosomiasis and treatment needs in sub-Saharan Africa: a systematic review and geostatistical analysis (Publications)
sis and rigorous variable selection to predict infection risk over a grid of 1?155?818 pixels at 5?×?5 km, on the basis of environmental and socioeconomic predictors and to calculate the number of doses [...] suggest that 163 million (95% Bayesian credible interval [CrI] 155 million to 172 million; 18·5%, 17·6-19·5) of the sub-Saharan African population was infected in 2012. Mozambique had the highest prevalence
Spatial variation and land use regression modeling of the oxidative potential of fine particles (Publications)
and to develop and evaluate LUR models to assess long-term exposure to the OP of PM2.5. METHODS: Three 2-week PM2.5 samples were collected at 10 regional background, 12 urban background, and 18 street [...] model predictions were moderately to highly correlated with predictions from a previously published PM2.5 model (R2 = 0.37-0.52), and highly correlated with predictions from previously published models of traffic [...] of the two OP metrics. The moderate correlations among the predictions of...
A cohort study of survival following discharge from hospital in rural Tanzanian children using linked data of admissions with community-based... (Publications)
surveillance were used to describe post-discharge mortality and survival probability in children aged < 5 years, by age group and cause of admission. Cox regression models were developed to identify risk factors [...] RESULTS: Between March 2003 and March 2007, demographic surveillance included 28,910 children aged 0 to 5 years and among them 831 (3%) were admitted at least once to the district hospital. From all the children [...] years and 1381 deaths were observed in 24 months of follow up....
Recent HIV-1 infection: identification of individuals with high viral load setpoint in a voluntary counselling and testing centre in rural Mozambique (Publications)
significantly higher HIV-viral load at all visits with a median HIV-RNA setpoint of 5.22 log(10) copies/mL (IQR 5.18-5.47) as compared to the median of 4.15 log(10) copies/ml (IQR 3.37-4.43) for the other [...] of HIV-RNA-setpoint may serve to identify recently infected individuals maintaining HIV viral load> 5 log10 copies/mL as candidates for antiretroviral treatment as prevention interventions
Risk factors of brucellosis seropositivity in Bactrian camels of Mongolia (Publications)
(odds ratio 13.2, 95% CI 5.3-32.4). Camel seroprevalences were stable over the two consecutive survey years, despite introduction of ruminant vaccination: 5.7% (95% CI 3.1-10.2%) and 5.8% (3.3-10.1%) in Eastern [...] Eastern provinces and 0.4% (0.2-1.2%) and 0.5% (0.1-2.0%) in Southern & Western provinces. We isolated Brucella abortus from camels and cattle. Camel seropositivity was associated to keeping cattle together
Spatial mapping and prediction of <em>Plasmodium falciparum</em> infection risk among school-aged children in Côte d'Ivoire (Publications)
kriging. RESULTS: Complete data sets were available from 5,322 children aged 5-16 years across Cote d'Ivoire. P. falciparum was the predominant species (94.5 %). The Bayesian geostatistical variable selection [...] cross-sectional survey was conducted, including parasitological examinations and interviews with more than 5,000 children from 93 schools across Cote d'Ivoire. A finger-prick blood sample was obtained from each