Pharmacokinetics of ivermectin metabolites and their activity against <em>Anopheles stephensi </em>mosquitoes (Publications)
METHODS: Ivermectin was incubated in the presence of recombinant human cytochrome P(450) 3A4/5 (CYP 3A4/5) to produce ivermectin metabolites. In total, nine metabolites were purified by semi-preparative [...] ivermectin more rapidly than CYP3A5. Ivermectin metabolites M1-M8 were predominantly formed by CYP3A4, whereas metabolite M9 (hydroxy-H(2)B(1a)) was mainly produced by CYP3A5. Both desmethyl-H(2)B(1a) (M1) [...] against An. stephensi at C(max) levels. Interestingly, half-lives of M1 (54.2...
The consequences of declining population access to insecticide-treated nets (ITNs) on net use patterns and physical degradation of nets after 22... (Publications)
77.5% of members slept under ITNs. In households without sufficient nets, pregnant women (54.6%), children < 5 years (45.8%) and adults (42.1%) were prioritized, with fewer school-age children 5-14 years [...] common among people residing in houses without sufficient nets for all age groups, apart from children < 5. Nets were less likely to be serviceable if: [Formula: see text] 3 people slept under them (OR 0.50 [...] CONCLUSION: Users determined the useful life of ITNs and prioritized...
CD4 surveillance in Scotland: perspectives on severe HIV-related immunodeficiency (Publications)
count was higher in women (by 2.1; SE, 0.5), in injecting drug users (IDU; by 1.8; SE, 0.5) and in younger patients (by 1.5 per 10 years; SE, 0.2), but reduced by 1.5 (SE, 0.1) per calendar year of recruitment [...] patients in 1993-1994 with a first CD4 count of > or = 500 x 10(6)/l had seroconverted within the past 5 years. Two-thirds of non-IDU (67%; 348 out of 517) were already severely immunodeficient at or before
Evaluation of the pharmacokinetic profile of artesunate, artemether and their metabolites in sheep naturally infected with <em>Fasciola hepatica</em> (Publications)
artesunate (C(max): 8.4x10(3) and 9.4x10(3)ng/ml; AUC: 6.9x10(5) and 9.7x10(5)ngmin/ml), DHA (C(max): both 2.4x10(3)ng/ml; AUC: 3.7x10(5) and 5.0x10(5)ngmin/ml), and DHA-glucuronide (C(max): 1.7x10(4) and 1
Use of portable exposimeters to monitor radiofrequency electromagnetic field exposure in the everyday environment (Publications)
outdoor microenvironments from 20 different municipalities in Switzerland: 5 different city centers, 5 central residential areas, 5 non-central residential areas, 15 rural residential areas, 15 rural centers [...] months on the same paths. Results: Mean RF-EMF exposure (sum of 15 main frequency bands between 87.5 and 5,875 MHz) was 0.53 V/m in industrial zones, 0.47 V/m in city centers, 0.32 V/m in central residential
Current allergic asthma and rhinitis: diagnostic efficiency of three commonly used atopic markers (IgE, skin prick tests, and Phadiatop). Results from... (Publications)
y of Phadiatop was significantly higher than that of SPT (72.5% vs 65.4%, 77.1% vs 68.4% respectively; P < 0.01 and < 0.001) and IgE (72.5% vs 56.9%, 77.1% vs 43.9%, respectively; both P < 0.001). The [...] vs 80.5%, respectively; both P < 0.001): when CAR was excluded, SPT was significantly higher than IgE (85.9 vs 81.4%; P < 0.001). SPT had significantly the best positive predictive value for CAA (5.2% for [...] for SPT vs 4.6% for both IgE and Phadiatop; both P < 0.001) and CAR (48.7% for SPT...
CD4 surveillance in Scotland: perspectives on severe HIV-related immunodeficiency (Publications)
count was higher in women (by 2.1; SE, 0.5), in injecting drug users (IDU; by 1.8; SE, 0.5) and in younger patients (by 1.5 per 10 years; SE, 0.2), but reduced by 1.5 (SE, 0.1) per calendar year of recruitment [...] patients in 1993-1994 with a first CD4 count of > or = 500 x 10(6)/l had seroconverted within the past 5 years. Two-thirds of non-IDU (67%; 348 out of 517) were already severely immunodeficient at or before
Evaluation of the pharmacokinetic profile of artesunate, artemether and their metabolites in sheep naturally infected with <em>Fasciola hepatica</em> (Publications)
artesunate (C(max): 8.4x10(3) and 9.4x10(3)ng/ml; AUC: 6.9x10(5) and 9.7x10(5)ngmin/ml), DHA (C(max): both 2.4x10(3)ng/ml; AUC: 3.7x10(5) and 5.0x10(5)ngmin/ml), and DHA-glucuronide (C(max): 1.7x10(4) and 1
Pharmacokinetics of ivermectin metabolites and their activity against <em>Anopheles stephensi </em>mosquitoes (Publications)
METHODS: Ivermectin was incubated in the presence of recombinant human cytochrome P(450) 3A4/5 (CYP 3A4/5) to produce ivermectin metabolites. In total, nine metabolites were purified by semi-preparative [...] ivermectin more rapidly than CYP3A5. Ivermectin metabolites M1-M8 were predominantly formed by CYP3A4, whereas metabolite M9 (hydroxy-H(2)B(1a)) was mainly produced by CYP3A5. Both desmethyl-H(2)B(1a) (M1) [...] against An. stephensi at C(max) levels. Interestingly, half-lives of M1 (54.2...
Participation in organised sports and longitudinal development of physical activity in Swiss youth: the population-based SOPHYA cohort (Publications)
decline from 2014 to 2019, but an increase in SB. Nevertheless, the prevalence of improvers was 22.5% for CPM, 9.5% for MVPA, 26.9% for LPA and 9.7% for SB. Engagement in organised sport between 2014 and 2019 [...] is associated with sustaining or enhancing physical activity among children and adolescents during 5 years of follow-up. METHODS: The longitudinal study was nested in the population-based SOPHYA (Swiss [...] the Y+S database as the number of days with at least one activity in...